Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil

Bibliographic Details
Main Author: Kauffman, Carla
Publication Date: 2019
Other Authors: Giacomin, Ana Caroline, Arossi, Kelen, Pacheco, Leandra Andressa, Hoehne, Lucélia, Freitas, Elisete Maria de, Machado, Gérzia Maria de Carvalho, Cavalheiro, Marilene Marcuzzo do Canto, Gnoatto, Simone Cristina Baggio, Ethur, Eduardo Miranda
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/s2175-97902019000217584
Download full: https://arca.fiocruz.br/handle/icict/37371
Summary: Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.
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spelling Kauffman, CarlaGiacomin, Ana CarolineArossi, KelenPacheco, Leandra AndressaHoehne, LucéliaFreitas, Elisete Maria deMachado, Gérzia Maria de CarvalhoCavalheiro, Marilene Marcuzzo do CantoGnoatto, Simone Cristina BaggioEthur, Eduardo Miranda2019-11-26T11:22:40Z2019-11-26T11:22:40Z2019KAUFFMANN, Carla et al. Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 55, p. 1-8, 2019.2175-9790https://arca.fiocruz.br/handle/icict/3737110.1590/s2175-97902019000217584engUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasLeishmania infantumMyrciaria plinioidesLeishmania amazonensisAtividade AntileishmanialLeishmania infantumMyrciaria plinioidesLeishmania amazonensisAntileishmanial activityAntileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.Universidade do Vale do Taquari. Centro de Ciências Exatas e Tecnológicas. Lajeado, RS, Brasil.Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.In South American folk medicine members of the genus Myrciaria are used for the treatment of malaria, diarrhoea, asthma, inflammation and post-partum uterine cleansing. The aim of this work was to evaluate its antileishmanial properties (in vitro) of essential oil derived from leaves of Myrciaria plinioides D. Legrand, a plant species that is native in South of Brazil. The essential oil was obtained by hydro-distillation using fresh leaves of M. plinioides. The chemical composition of this essential oil (MPEO, M. plinioides essential oil) was determined by gas chromatography coupled to mass spectrometry (GC‑MS). MPEO was assayed in vitro for antileishmanial properties against promastigotes of Leishmania amazonensis and Leishmania infantum, and for cytotoxicity against murine peritoneal macrophages. The MPEO comprised 66 components and was rich in oxygenated sesquiterpenes (82.66%) containing spathulenol (21.12%) as its major constituent. The MPEO was effective against L. amazonensis with IC50 value of 14.16 ± 7.40 µg/mL, while against L. infantum the IC50 value was higher with 101.50 ± 5.78 µg/mL. The MPEO showed significant activity against L. amazonensis, and presented a selectivity index (SI) of 6.60. The results suggest that the essential oil from leaves of M. plinioides is a promising source for new antileishmanial agents against L. amazonensis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/afc88f9a-1a59-4035-a5d8-e6e756371a2b/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALMarileneMCavalheiro_etal_IOC_2019.pdfMarileneMCavalheiro_etal_IOC_2019.pdfapplication/pdf389480https://arca.fiocruz.br/bitstreams/9b7ac7b6-0ebf-41b0-af0d-4a2647f2f444/downloadb69b52dc72bbc14cc7f02cb9e26f1a93MD52trueAnonymousREADTEXTMarileneMCavalheiro_etal_IOC_2019.pdf.txtMarileneMCavalheiro_etal_IOC_2019.pdf.txtExtracted texttext/plain33114https://arca.fiocruz.br/bitstreams/77e0d7fa-df48-4417-9f53-b43359f37fb3/download11fd5c57b1408913d4d3552350625977MD55falseAnonymousREADTHUMBNAILMarileneMCavalheiro_etal_IOC_2019.pdf.jpgMarileneMCavalheiro_etal_IOC_2019.pdf.jpgGenerated Thumbnailimage/jpeg6031https://arca.fiocruz.br/bitstreams/21a8ef42-1aae-4c43-b3ef-2a3e46416588/download6594e6b6f34572b7c24425532462a157MD56falseAnonymousREADicict/373712025-07-29 23:05:37.145open.accessoai:arca.fiocruz.br:icict/37371https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T02:05:37Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
title Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
spellingShingle Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
Kauffman, Carla
Leishmania infantum
Myrciaria plinioides
Leishmania amazonensis
Atividade Antileishmanial
Leishmania infantum
Myrciaria plinioides
Leishmania amazonensis
Antileishmanial activity
title_short Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
title_full Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
title_fullStr Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
title_full_unstemmed Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
title_sort Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
author Kauffman, Carla
author_facet Kauffman, Carla
Giacomin, Ana Caroline
Arossi, Kelen
Pacheco, Leandra Andressa
Hoehne, Lucélia
Freitas, Elisete Maria de
Machado, Gérzia Maria de Carvalho
Cavalheiro, Marilene Marcuzzo do Canto
Gnoatto, Simone Cristina Baggio
Ethur, Eduardo Miranda
author_role author
author2 Giacomin, Ana Caroline
Arossi, Kelen
Pacheco, Leandra Andressa
Hoehne, Lucélia
Freitas, Elisete Maria de
Machado, Gérzia Maria de Carvalho
Cavalheiro, Marilene Marcuzzo do Canto
Gnoatto, Simone Cristina Baggio
Ethur, Eduardo Miranda
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kauffman, Carla
Giacomin, Ana Caroline
Arossi, Kelen
Pacheco, Leandra Andressa
Hoehne, Lucélia
Freitas, Elisete Maria de
Machado, Gérzia Maria de Carvalho
Cavalheiro, Marilene Marcuzzo do Canto
Gnoatto, Simone Cristina Baggio
Ethur, Eduardo Miranda
dc.subject.other.none.fl_str_mv Leishmania infantum
Myrciaria plinioides
Leishmania amazonensis
Atividade Antileishmanial
topic Leishmania infantum
Myrciaria plinioides
Leishmania amazonensis
Atividade Antileishmanial
Leishmania infantum
Myrciaria plinioides
Leishmania amazonensis
Antileishmanial activity
dc.subject.en.none.fl_str_mv Leishmania infantum
Myrciaria plinioides
Leishmania amazonensis
Antileishmanial activity
description Universidade do Vale do Taquari. Centro de Ciências Biológicas e da Saúde. Lajeado, RS, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-11-26T11:22:40Z
dc.date.available.fl_str_mv 2019-11-26T11:22:40Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KAUFFMANN, Carla et al. Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 55, p. 1-8, 2019.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/37371
dc.identifier.issn.none.fl_str_mv 2175-9790
dc.identifier.doi.none.fl_str_mv 10.1590/s2175-97902019000217584
identifier_str_mv KAUFFMANN, Carla et al. Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil. Brazilian Journal of Pharmaceutical Sciences, São Paulo, v. 55, p. 1-8, 2019.
2175-9790
10.1590/s2175-97902019000217584
url https://arca.fiocruz.br/handle/icict/37371
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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