Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation

Bibliographic Details
Main Author: Saraiva, Roberto M.
Publication Date: 2009
Other Authors: Yamano, Tetsuhiro, Matsumura, Yoshiki, Takasaki, Kunitsugu, Toyono, Manatomo, Agler, Deborah A., Greenberg, Neil, Thomas, James D., Shiota, Takahiro
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.ahj.2009.05.030
Download full: https://arca.fiocruz.br/handle/icict/39065
Summary: Roberto M. Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Saraiva, Roberto M.Yamano, TetsuhiroMatsumura, YoshikiTakasaki, KunitsuguToyono, ManatomoAgler, Deborah A.Greenberg, NeilThomas, James D.Shiota, Takahiro2020-01-08T14:27:34Z2020-01-08T14:27:34Z2009SARAIVA, Roberto M. et al. Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation. American Heart Journal, v. 158, p. 309-316, Aug. 2009.0002-8703https://arca.fiocruz.br/handle/icict/3906510.1016/j.ahj.2009.05.0301097-6744Roberto M. Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2021-01-08Cleveland Clinic. Department of Cardiovascular Medicine. Cleveland, OH, USA.Cleveland Clinic. Department of Cardiovascular Medicine. Cleveland, OH, USA.Cleveland Clinic. Department of Cardiovascular Medicine. Cleveland, OH, USA.Cleveland Clinic. Department of Cardiovascular Medicine. Cleveland, OH, USA.Cleveland Clinic. Department of Cardiovascular Medicine. Cleveland, OH, USA.Cleveland Clinic. Department of Cardiovascular Medicine. Cleveland, OH, USA.Cleveland Clinic. Department of Cardiovascular Medicine. Cleveland, OH, USA.Cleveland Clinic. Department of Cardiovascular Medicine. Cleveland, OH, USA.Cedars-Sinai Medical Center. Department of Cardiology. Los Angeles, CA, USA / University of California. David Geffen School of Medicine. Los Angeles, CA, USA.Background: Left atrial (LA) volume is a prognostic index in chronic mitral regurgitation (MR). However, little is known about LA function in this setting. We hypothesized that LA dysfunction is related to pulmonary hypertension in chronic MR. Methods: Seventy-one patients with organic chronic MR who underwent real-time 3-dimensional transthoracic echocardiography (RT3DE) were studied. Left atrial volumes and peak passive and active LA emptying rates were obtained.Total LA emptying fraction was calculated as follows: [(maximum−minimum LA volume)/maximum LA volume] × 100. Similarly,active and passive LA emptying fractions were calculated. From transmitral flow, the peak early (E) and late (A) diastolic filling velocities and E/A ratio were obtained. The early (E′) and late (A′) diastolic myocardial velocities were obtained by tissue Doppler interrogation of mitral annulus.ResultsEffective regurgitant orifice area (EROA) was 0.57 ± 0.29 cm2. Right ventricular systolic pressure (RVSP) wasmeasured in 57 patients and averaged 37 ± 13 mm Hg. Patients with MR and high RVSP displayed higher minimum LA volume,E/A ratio, E/E′ratio, EROA, and MR volume, and lower A′velocity, peak active LA emptying rate, active LA emptying fraction,and total LA emptying fraction than patients with MR and normal RVSP. Multiple regression analysis revealed that EROA(r= 0.51,P= .01) active LA emptying fraction (r=−0.53,P= .02), E/E′ ratio (r= 0.50;P= .04), and the lateral A′ velocity(r=−0.46; P= .003) were independently correlated with RVSP. Conclusions: Left atrial function determined by RT3DE had significant correlation with RVSP in chronic MR, irrespective of MR severity. Thus, pulmonary hypertension in chronic MR may depend not only on MR severity but also on LA function.engElsevierLeft atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLeft atrial functionChronic mitral regurgitationEchocardiographyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://arca.fiocruz.br/bitstreams/36e0ca1a-035a-4023-b9c0-abeec410d335/download8a4605be74aa9ea9d79846c1fba20a33MD51falseAnonymousREADORIGINALve_Saraiva_Roberto_etal_INI_2009.pdfve_Saraiva_Roberto_etal_INI_2009.pdfapplication/pdf332513https://arca.fiocruz.br/bitstreams/b313d72c-547a-4af9-a1b5-8e43fd00cb4d/download22f5c54ad70b8ffa8595d220ae1165c7MD52trueAnonymousREAD2021-01-08TEXTve_Saraiva_Roberto_etal_INI_2009.pdf.txtve_Saraiva_Roberto_etal_INI_2009.pdf.txtExtracted texttext/plain34606https://arca.fiocruz.br/bitstreams/b75a0afe-b579-4cf1-bc14-cb8750a80ea3/download5c3e724d4ae109f6a5209b200f17eef3MD55falseAnonymousREAD2021-01-08THUMBNAILve_Saraiva_Roberto_etal_INI_2009.pdf.jpgve_Saraiva_Roberto_etal_INI_2009.pdf.jpgGenerated Thumbnailimage/jpeg6092https://arca.fiocruz.br/bitstreams/f997d9c9-a13c-41cf-9160-361c19253a41/downloadff7b9eaab4955ad4d114f1c469517623MD56falseAnonymousREAD2021-01-08icict/390652025-07-29 21:10:40.204open.accessoai:arca.fiocruz.br:icict/39065https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T00:10:40Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
dc.title.none.fl_str_mv Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation
title Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation
spellingShingle Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation
Saraiva, Roberto M.
Left atrial function
Chronic mitral regurgitation
Echocardiography
title_short Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation
title_full Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation
title_fullStr Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation
title_full_unstemmed Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation
title_sort Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation
author Saraiva, Roberto M.
author_facet Saraiva, Roberto M.
Yamano, Tetsuhiro
Matsumura, Yoshiki
Takasaki, Kunitsugu
Toyono, Manatomo
Agler, Deborah A.
Greenberg, Neil
Thomas, James D.
Shiota, Takahiro
author_role author
author2 Yamano, Tetsuhiro
Matsumura, Yoshiki
Takasaki, Kunitsugu
Toyono, Manatomo
Agler, Deborah A.
Greenberg, Neil
Thomas, James D.
Shiota, Takahiro
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Saraiva, Roberto M.
Yamano, Tetsuhiro
Matsumura, Yoshiki
Takasaki, Kunitsugu
Toyono, Manatomo
Agler, Deborah A.
Greenberg, Neil
Thomas, James D.
Shiota, Takahiro
dc.subject.en.none.fl_str_mv Left atrial function
Chronic mitral regurgitation
Echocardiography
topic Left atrial function
Chronic mitral regurgitation
Echocardiography
description Roberto M. Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2020-01-08T14:27:34Z
dc.date.available.fl_str_mv 2020-01-08T14:27:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SARAIVA, Roberto M. et al. Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation. American Heart Journal, v. 158, p. 309-316, Aug. 2009.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/39065
dc.identifier.issn.none.fl_str_mv 0002-8703
dc.identifier.doi.none.fl_str_mv 10.1016/j.ahj.2009.05.030
dc.identifier.eissn.none.fl_str_mv 1097-6744
identifier_str_mv SARAIVA, Roberto M. et al. Left atrial function assessed by real-time 3-dimensional echocardiography is related to right ventricular systolic pressure in chronic mitral regurgitation. American Heart Journal, v. 158, p. 309-316, Aug. 2009.
0002-8703
10.1016/j.ahj.2009.05.030
1097-6744
url https://arca.fiocruz.br/handle/icict/39065
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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