Determinants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study
| Main Author: | |
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| Publication Date: | 2020 |
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| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1016/j.ijid.2020.02.015 |
| Download full: | https://arca.fiocruz.br/handle/icict/49494 |
Summary: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Finance Code001) |
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Araujo, Nelia Cláudia NeriCruz, Constança Margarida SampaioArriaga Gutiérrez, María BelenCubillos-Angulo, Juan ManuelRocha, Michael SantosMattos, Paulo Sérgio de Morais da SilveiraMatos, Gisela M.Marques, Izabella M. B.Espírito Santo, Isa Carolina Paim doAlmeida, Luiza L.Andrade, Caroline M.Souza, Leonardo Azevedo deMartins Netto, EduardoAndrade, Bruno de Bezerril2021-10-20T09:35:58Z2021-10-20T09:35:58Z2020ARAUJO, Nelia Cláudia Neri et al. Determinants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study. International Journal of Infectious Diseases, v. 93, p. 277-283, 18 Feb. 2020.1201-9712https://arca.fiocruz.br/handle/icict/4949410.1016/j.ijid.2020.02.015Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Finance Code001)National Institutes of Health (U01AI115940)Departamento de Ciência e Tecnologia (DECIT) - Secretaria de Ciência e Tecnologia (SCTIE) – Ministério da Saúde (MS), Brazil (25029.000507/2013-070)Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB)Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Obras Sociais Irmã Dulce. Salvador, BA, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil.Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities. Salvador, BA, Brasil.Background: The present study evaluated factors associated with losses in the latent tuberculosis infection (LTBI) cascade of care in contacts of tuberculosis (TB) patients, in a referral center from a highly endemic region in Brazil. Methods: Contacts of 1672 TB patients were retrospectively studied between 2009 and 2014. Data on TB screening by clinical investigation, radiographic examination and tuberculin skin test (TST) were extracted from medical records. Losses in the cascade of care and TB incidence within 2-year follow-up were calculated. Results: From a total of 1180 TB contacts initially identified, only 495 were examined (58% loss), and 20 were diagnosed with active TB at this stage. Furthermore, 435 persons returned for TST result interpretation and 351 (⁓81%) were TST positive. Among those with positive TST, 249 (73%) were treated with isoniazid for 6 months whereas 51 abandoned therapy early. Three individuals who did not receive LTBI treatment, one with incomplete treatment and another who completed treatment developed active TB. A logistic regression analysis revealed that increases in age were associated with losses in the LTBI cascade independent of other clinical and epidemiological characteristics. Conclusions: Major losses occur at initial stages and older patients are at higher risk of not completing the LTBI cascade of care.engElsevierTuberculoseInfecção latenteTratamentoTuberculosisLatent TB infectionLTBI cascadeTreatment for latent TBDeterminants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://arca.fiocruz.br/bitstreams/40dbce3c-aefb-43d9-86f7-823a0bd263bd/download36b51ef91c52b5338d9d29ba0cc807bcMD51falseAnonymousREADORIGINALve_María_Gutiérrez_etal_IGM_2020.pdfve_María_Gutiérrez_etal_IGM_2020.pdfArtigo em Inglêsapplication/pdf1173474https://arca.fiocruz.br/bitstreams/e3de631a-04dc-4d60-9b20-520d40ec4cdc/download92378c33b3a49c27982fa133e4b08c01MD53trueAnonymousREADAraujo, Nélia C.N. 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| dc.title.none.fl_str_mv |
Determinants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study |
| title |
Determinants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study |
| spellingShingle |
Determinants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study Araujo, Nelia Cláudia Neri Tuberculose Infecção latente Tratamento Tuberculosis Latent TB infection LTBI cascade Treatment for latent TB |
| title_short |
Determinants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study |
| title_full |
Determinants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study |
| title_fullStr |
Determinants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study |
| title_full_unstemmed |
Determinants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study |
| title_sort |
Determinants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study |
| author |
Araujo, Nelia Cláudia Neri |
| author_facet |
Araujo, Nelia Cláudia Neri Cruz, Constança Margarida Sampaio Arriaga Gutiérrez, María Belen Cubillos-Angulo, Juan Manuel Rocha, Michael Santos Mattos, Paulo Sérgio de Morais da Silveira Matos, Gisela M. Marques, Izabella M. B. Espírito Santo, Isa Carolina Paim do Almeida, Luiza L. Andrade, Caroline M. Souza, Leonardo Azevedo de Martins Netto, Eduardo Andrade, Bruno de Bezerril |
| author_role |
author |
| author2 |
Cruz, Constança Margarida Sampaio Arriaga Gutiérrez, María Belen Cubillos-Angulo, Juan Manuel Rocha, Michael Santos Mattos, Paulo Sérgio de Morais da Silveira Matos, Gisela M. Marques, Izabella M. B. Espírito Santo, Isa Carolina Paim do Almeida, Luiza L. Andrade, Caroline M. Souza, Leonardo Azevedo de Martins Netto, Eduardo Andrade, Bruno de Bezerril |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Araujo, Nelia Cláudia Neri Cruz, Constança Margarida Sampaio Arriaga Gutiérrez, María Belen Cubillos-Angulo, Juan Manuel Rocha, Michael Santos Mattos, Paulo Sérgio de Morais da Silveira Matos, Gisela M. Marques, Izabella M. B. Espírito Santo, Isa Carolina Paim do Almeida, Luiza L. Andrade, Caroline M. Souza, Leonardo Azevedo de Martins Netto, Eduardo Andrade, Bruno de Bezerril |
| dc.subject.other.none.fl_str_mv |
Tuberculose Infecção latente Tratamento |
| topic |
Tuberculose Infecção latente Tratamento Tuberculosis Latent TB infection LTBI cascade Treatment for latent TB |
| dc.subject.en.none.fl_str_mv |
Tuberculosis Latent TB infection LTBI cascade Treatment for latent TB |
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Finance Code001) |
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2020 |
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2020 |
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2021-10-20T09:35:58Z |
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2021-10-20T09:35:58Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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ARAUJO, Nelia Cláudia Neri et al. Determinants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study. International Journal of Infectious Diseases, v. 93, p. 277-283, 18 Feb. 2020. |
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https://arca.fiocruz.br/handle/icict/49494 |
| dc.identifier.issn.none.fl_str_mv |
1201-9712 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.ijid.2020.02.015 |
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ARAUJO, Nelia Cláudia Neri et al. Determinants of losses in the latent tuberculosis cascade of care in Brazil: a retrospective cohort study. International Journal of Infectious Diseases, v. 93, p. 277-283, 18 Feb. 2020. 1201-9712 10.1016/j.ijid.2020.02.015 |
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Elsevier |
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Elsevier |
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