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Long-term quality of life among survivors of severe sepsis: analyses of two international trials

Bibliographic Details
Main Author: Yende, Sachin
Publication Date: 2016
Other Authors: Austin, Shamly, Rhodes, Andrew, Finfer, Simon, Opal, Steven, Thompson, Taylor, Bozza, Fernando A., Larosa, Steven P., Ranieri, V. Marco, Angus, Derek C.
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1097/CCM.0000000000001658
Download full: https://arca.fiocruz.br/handle/icict/32408
Summary: 2020-04-08
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spelling Yende, SachinAustin, ShamlyRhodes, AndrewFinfer, SimonOpal, StevenThompson, TaylorBozza, Fernando A.Larosa, Steven P.Ranieri, V. MarcoAngus, Derek C.2019-04-08T14:22:41Z2019-04-08T14:22:41Z2016YENDE, Sachin et al. Long-term quality of life among survivors of several sepsis: analyses of two international trialals. Critical Care Medicine, v. 44, n. 8, p. 1461-1467, Aug. 2016.0090-3493https://arca.fiocruz.br/handle/icict/3240810.1097/CCM.0000000000001658engLippincott, Williams & WilkinsLong-term quality of life among survivors of severe sepsis: analyses of two international trialsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-04-08University of Pittsburgh. The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center. Department of Critical Care Medicine. Pittsburgh, PA, USA / Veterans Affairs Pittsburgh Healthcare System. Pittsburg, PA, USA.University of Pittsburgh. The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center. Department of Critical Care Medicine. Pittsburgh, PA, USA / Gateway Health. Research and Development, Quality Improvement Department. Pittsburgh PA, USA.St. George’s University Hospitals NHS Foundation Trust. Adult Critical Care. London, UK.University of Sydney. The George Institute for Global Health. Sydney, NSW, Australia.Alpert Medical School of Brown University. Infectious Disease Division. Pawtucket, RI, USA.Massachusetts General Hospital. Pulmonary and Critical Care Division. Boston, MA, USA.University of Pittsburgh. The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center. Department of Critical Care Medicine. Pittsburgh, PA, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Lahey Health System. Beverly Hospital. Beverly, MA, USA.University Sapienza of Rome. Policlino Umberto I Hospital. Department of Anesthesia and Intensive Care Medicine. Rome, Italy.University of Pittsburgh. The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center. Department of Critical Care Medicine. Pittsburgh, PA, USA.Objective: To describe quality of life (QoL) among sepsis survivors. Design: Secondary analyses of 2 international, randomized clinical trials (ACCESS [derivation cohort] and PROWESS-SHOCK [validation cohort]). Patients: Adults with severe sepsis admitted to the intensive care unit. We analyzed only patients who were functional and living at home without help before sepsis hospitalization (n=1,143 and 987 from ACCESS and PROWESS-SHOCK). Measurements and Main Results: In ACCESS and PROWESS-SHOCK, the average age of patients living at home independently was 63 and 61 years; 400 (34.9%) and 298 (30.2%) died by 6 months. In ACCESS, 580 patients had a QoL measured using EQ-5D at 6 months. Of these, 41.6% could not live independently (22.7% were home but required help, 5.1% were in nursing home or rehabilitation facilities, and 5.3% were in acute care hospitals). Poor QoL at 6 months, as evidenced by problems in mobility, usual activities, and self-care domains were reported in 37.4%, 43.7%, and 20.5%, respectively, and the high incidence of poor QoL was also seen in patients in PROWESS-SHOCK. Over 45%of patients with mobility and self-care problems at 6 months in ACCESS died or reported persistent problems at 1 year. Conclusions: Among individuals enrolled in a clinical trial who lived independently prior to severe sepsis, one third had died and of those who survived, a further one third had not returned to independent living by 6 months. 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dc.title.none.fl_str_mv Long-term quality of life among survivors of severe sepsis: analyses of two international trials
title Long-term quality of life among survivors of severe sepsis: analyses of two international trials
spellingShingle Long-term quality of life among survivors of severe sepsis: analyses of two international trials
Yende, Sachin
Survivors of severe sepsis
Clinical trials
title_short Long-term quality of life among survivors of severe sepsis: analyses of two international trials
title_full Long-term quality of life among survivors of severe sepsis: analyses of two international trials
title_fullStr Long-term quality of life among survivors of severe sepsis: analyses of two international trials
title_full_unstemmed Long-term quality of life among survivors of severe sepsis: analyses of two international trials
title_sort Long-term quality of life among survivors of severe sepsis: analyses of two international trials
author Yende, Sachin
author_facet Yende, Sachin
Austin, Shamly
Rhodes, Andrew
Finfer, Simon
Opal, Steven
Thompson, Taylor
Bozza, Fernando A.
Larosa, Steven P.
Ranieri, V. Marco
Angus, Derek C.
author_role author
author2 Austin, Shamly
Rhodes, Andrew
Finfer, Simon
Opal, Steven
Thompson, Taylor
Bozza, Fernando A.
Larosa, Steven P.
Ranieri, V. Marco
Angus, Derek C.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Yende, Sachin
Austin, Shamly
Rhodes, Andrew
Finfer, Simon
Opal, Steven
Thompson, Taylor
Bozza, Fernando A.
Larosa, Steven P.
Ranieri, V. Marco
Angus, Derek C.
dc.subject.en.none.fl_str_mv Survivors of severe sepsis
Clinical trials
topic Survivors of severe sepsis
Clinical trials
description 2020-04-08
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-04-08T14:22:41Z
dc.date.available.fl_str_mv 2019-04-08T14:22:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv YENDE, Sachin et al. Long-term quality of life among survivors of several sepsis: analyses of two international trialals. Critical Care Medicine, v. 44, n. 8, p. 1461-1467, Aug. 2016.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/32408
dc.identifier.issn.none.fl_str_mv 0090-3493
dc.identifier.doi.none.fl_str_mv 10.1097/CCM.0000000000001658
identifier_str_mv YENDE, Sachin et al. Long-term quality of life among survivors of several sepsis: analyses of two international trialals. Critical Care Medicine, v. 44, n. 8, p. 1461-1467, Aug. 2016.
0090-3493
10.1097/CCM.0000000000001658
url https://arca.fiocruz.br/handle/icict/32408
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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