Serotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy
| Main Author: | |
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| Publication Date: | 2016 |
| Other Authors: | , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1186/s12866-016-0747-y |
| Download full: | https://arca.fiocruz.br/handle/icict/18099 |
Summary: | Produção científica do Laboratório de Hanseníase. |
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Nhantumbo, Aquino AlbinoGudo, Eduardo SamoCaierão, JulianaMunguambe, Alcides MonizComé, Charlotte ElizabethZimba, Tomás FranciscoMoraes, Milton OzórioDias, Cícero Armídio GomesCantarelli, Vlademir Vicente2017-03-21T14:47:09Z2017-03-21T14:47:09Z2016NHANTUMBO, Aquino Albino et al. Serotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy. BMC Microbiology, v. 16, n. 134, p. 1-9, 29 June 2016.1471-2180https://arca.fiocruz.br/handle/icict/1809910.1186/s12866-016-0747-y1471-2180Produção científica do Laboratório de Hanseníase.Ministério da Saúde. Instituto Nacional de Saúde. Laboratório Nacional de Referência de Microbiologia. Maputo, Mozambique / Instituto Nacional de Saúde. Laboratório Nacional de Referência de Microbiologia. Maputo, Mozambique.Ministério da Saúde. Instituto Nacional de Saúde. Maputo, Mozambique.Universidade Federal de Ciências de Saúde de Porto Alegre. Porto Alegre, RS, Brasil.Ministério da Saúde. Instituto Nacional de Saúde. Laboratório Nacional de Referência de Microbiologia. Maputo, Mozambique.Ministério da Saúde. Instituto Nacional de Saúde. Laboratório Nacional de Referência de Microbiologia. Maputo, Mozambique.Hospital Central de Maputo. Departamento de Medicina. Maputo, Mozambique.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Universidade Federal de Ciências de Saúde de Porto Alegre. Porto Alegre, RS, Brasil.Universidade Feevale. Novo Hamburgo, RS, Brasil / Universidade Federal de Ciências de Saúde de Porto Alegre. Porto Alegre, RS, Brasil.Background: S. pneumoniae is the leading cause of acute bacterial meningitis (ABM) in children. Vaccination using the 10-valent conjugate vaccine (PCV-10) was recently introduced into the National Immunization Program in Mozambique, but data on serotype coverage of this vaccine formulation are scarce. In this study, we investigated the serotype distribution and antimicrobial resistance of isolates of S. pneumoniae causing ABM in children < 5 years at the two largest hospitals in Mozambique. Methods: Between March 2013 and March 2014, a total of 352 cerebrospinal fluid (CSF) samples were collected from eligible children, of which 119 (33.8 %) were positive for S. pneumoniae. Of these, only 50 samples met the criteria for serotyping and were subsequently serotyped using sequential multiplex PCR (SM-PCR), but 15 samples were non-typable. Results: The most common serotypes of S. pneumoniae were 1 (18.2 %), 5 (15.2 %), 14 (12.1 %), 9 V (12.1 %), 23 F (9.1 %), 6A (9.1 %), 4 (9.1 %) and 6B (6.1 %). Serotypes 1, 5, 9 V, 6A and 12 were mostly prevalent in Northern Mozambique, while serotypes 23 F, 4, 6B, 3 and 15B were predominant in Southern. Serotype coverage of PCV-10 and PCV-13 vaccine formulations were 81.8 % and 93.9 %, respectively. Serotypes 1, 3, 4, 6B, 14, 23 F were resistant to penicillin and sensitive to ceftriaxone. Conclusions: Our findings shows that changing the current in use PCV-10 vaccine formulation to PCV-13 formulation might increase substantially the protection against invasive strains of S. pneumoniae as the PCV-10 vaccine formulation does not cover the serotypes 3 and 6A, which are prevalent in Mozambique.engBMCMeningite pneumocócicaMoçambiquePneumococcal meningitisMozambiqueSerotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/e131925c-ce49-4e8c-9d08-3d229c4b151b/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALmilton3_moraes_etal_IOC_2016.pdfmilton3_moraes_etal_IOC_2016.pdfapplication/pdf1069144https://arca.fiocruz.br/bitstreams/7a167f2f-cb98-4aba-ae12-27f474c00164/download22537df14f6280959ff82885d546f476MD52trueAnonymousREADTEXTmilton3_moraes_etal_IOC_2016.pdf.txtmilton3_moraes_etal_IOC_2016.pdf.txtExtracted texttext/plain39103https://arca.fiocruz.br/bitstreams/81c9aae7-93da-4973-98a9-5d26aa2a97a9/downloadcf3488e1e3c9360ddad306b1846e35daMD56falseAnonymousREADTHUMBNAILcapa_Milton_Moraes_etal_IOC_2016.jpgcapa_Milton_Moraes_etal_IOC_2016.jpgCapaimage/jpeg2044494https://arca.fiocruz.br/bitstreams/1f0b66d8-3395-4ee7-8788-4138c23b73ab/downloadfcbec14e73edb72048d4f7cb047db5c6MD54falseAnonymousREADmilton3_moraes_etal_IOC_2016.pdf.jpgmilton3_moraes_etal_IOC_2016.pdf.jpgGenerated Thumbnailimage/jpeg5074https://arca.fiocruz.br/bitstreams/1d279e4a-d571-47a2-99be-2f6c42c4df55/download7c87c76a39d9f5155b8814433094724fMD57falseAnonymousREADicict/180992025-07-29 22:22:50.68open.accessoai:arca.fiocruz.br:icict/18099https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T01:22:50Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.none.fl_str_mv |
Serotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy |
| title |
Serotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy |
| spellingShingle |
Serotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy Nhantumbo, Aquino Albino Meningite pneumocócica Moçambique Pneumococcal meningitis Mozambique |
| title_short |
Serotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy |
| title_full |
Serotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy |
| title_fullStr |
Serotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy |
| title_full_unstemmed |
Serotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy |
| title_sort |
Serotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy |
| author |
Nhantumbo, Aquino Albino |
| author_facet |
Nhantumbo, Aquino Albino Gudo, Eduardo Samo Caierão, Juliana Munguambe, Alcides Moniz Comé, Charlotte Elizabeth Zimba, Tomás Francisco Moraes, Milton Ozório Dias, Cícero Armídio Gomes Cantarelli, Vlademir Vicente |
| author_role |
author |
| author2 |
Gudo, Eduardo Samo Caierão, Juliana Munguambe, Alcides Moniz Comé, Charlotte Elizabeth Zimba, Tomás Francisco Moraes, Milton Ozório Dias, Cícero Armídio Gomes Cantarelli, Vlademir Vicente |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Nhantumbo, Aquino Albino Gudo, Eduardo Samo Caierão, Juliana Munguambe, Alcides Moniz Comé, Charlotte Elizabeth Zimba, Tomás Francisco Moraes, Milton Ozório Dias, Cícero Armídio Gomes Cantarelli, Vlademir Vicente |
| dc.subject.other.none.fl_str_mv |
Meningite pneumocócica Moçambique |
| topic |
Meningite pneumocócica Moçambique Pneumococcal meningitis Mozambique |
| dc.subject.en.none.fl_str_mv |
Pneumococcal meningitis Mozambique |
| description |
Produção científica do Laboratório de Hanseníase. |
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2016 |
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2016 |
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2017-03-21T14:47:09Z |
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2017-03-21T14:47:09Z |
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NHANTUMBO, Aquino Albino et al. Serotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy. BMC Microbiology, v. 16, n. 134, p. 1-9, 29 June 2016. |
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https://arca.fiocruz.br/handle/icict/18099 |
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1471-2180 |
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10.1186/s12866-016-0747-y |
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1471-2180 |
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NHANTUMBO, Aquino Albino et al. Serotype distribution and antimicrobial resistance of streptococcus pneumoniae in children with acute bacterial meningitis in Mozambique: implications for a national immunization strategy. BMC Microbiology, v. 16, n. 134, p. 1-9, 29 June 2016. 1471-2180 10.1186/s12866-016-0747-y |
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