Decellularized extracellular matrix: the role of this complex biomaterial in regeneration

Bibliographic Details
Main Author: Paula, André Guilherme Portela de
Publication Date: 2023
Other Authors: Lima, Jordana Dinorá de, Bastos, Thais Sibioni Berti, Czaikovski, Andressa Pacheco, Luz, Rebeca Bosso dos Santos, Yuasa, Bruna Sadae, Smanioto, Caio Cesar Souza, Robert, Anny Waloski, Braga, Tárcio Teodoro
Format: Article
Language: por
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1021/acsomega.2c06216
Download full: https://arca.fiocruz.br/handle/icict/59716
Summary: Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.
id CRUZ_6355234fde08c11c4de7fc76ee8f3f9c
oai_identifier_str oai:arca.fiocruz.br:icict/59716
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Paula, André Guilherme Portela deLima, Jordana Dinorá deBastos, Thais Sibioni BertiCzaikovski, Andressa PachecoLuz, Rebeca Bosso dos SantosYuasa, Bruna SadaeSmanioto, Caio Cesar SouzaRobert, Anny WaloskiBraga, Tárcio Teodoro2023-07-21T17:16:56Z2023-07-21T17:16:56Z2023PAULA, André Guilherme Portela de et al. Decellularized extracellular matrix: the role of this complex biomaterial in regeneration. ACS Omega, v. 8, n. 25, p. 22256-22267, Jun. 2023.2470-1343https://arca.fiocruz.br/handle/icict/5971610.1021/acsomega.2c06216porAmerican Chemical SocietyDecellularized extracellular matrix: the role of this complex biomaterial in regenerationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Básica de Células Tronco. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil.Organ transplantation is understood as a technique where an organ from a donor patient is transferred to a recipient patient. This practice gained strength in the 20th century and ensured advances in areas of knowledge such as immunology and tissue engineering. The main problems that comprise the practice of transplants involve the demand for viable organs and immunological aspects related to organ rejection. In this review, we address advances in tissue engineering for reversing the current challenges of transplants, focusing on the possible use of decellularized tissues in tissue engineering. We address the interaction of acellular tissues with immune cells, especially macrophages and stem cells, due to their potential use in regenerative medicine. Our goal is to exhibit data that demonstrate the use of decellularized tissues as alternative biomaterials that can be applied clinically as partial or complete organ substitutes.Tissue EngineeringTransplantsDecellularized TissuesBiocompatible MaterialsStem CellsMacrophagesIngeniería de TejidosTrasplantesAcellular DermisMateriales BiocompatiblesCélulas MadreIngénierie tissulaireDerme acellulaireMatériaux biocompatiblesCellules souchesMacrophagesEngenharia TecidualTransplantesDerme AcelularBiomateriaisCélulas-TroncoMacrófagosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALao2c06216ok.pdfao2c06216ok.pdfapplication/pdf5495794https://arca.fiocruz.br/bitstreams/beea8a15-537c-4a70-a7e7-8486c585ef0d/download8dabde7462714eeea51e993cc0c0a943MD52trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/7363a86f-b67d-4b75-88a6-ebe53d67f2b2/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADTEXTao2c06216ok.pdf.txtao2c06216ok.pdf.txtExtracted texttext/plain95534https://arca.fiocruz.br/bitstreams/08d542e9-3bfd-41ea-aa31-9a5a46e3e11a/downloadf0eb5d6d5915851bad6a7b81e2bc3ca1MD57falseAnonymousREADTHUMBNAILao2c06216ok.pdf.jpgao2c06216ok.pdf.jpgGenerated Thumbnailimage/jpeg6716https://arca.fiocruz.br/bitstreams/b63863f4-5dbc-4332-9b2e-8f0958fc74c0/download552aa19be20e10653b6e567b4eeac7cfMD58falseAnonymousREADicict/597162025-07-29 19:23:31.037open.accessoai:arca.fiocruz.br:icict/59716https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T22:23:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
dc.title.none.fl_str_mv Decellularized extracellular matrix: the role of this complex biomaterial in regeneration
title Decellularized extracellular matrix: the role of this complex biomaterial in regeneration
spellingShingle Decellularized extracellular matrix: the role of this complex biomaterial in regeneration
Paula, André Guilherme Portela de
Tissue Engineering
Transplants
Decellularized Tissues
Biocompatible Materials
Stem Cells
Macrophages
Ingeniería de Tejidos
Trasplantes
Acellular Dermis
Materiales Biocompatibles
Células Madre
Ingénierie tissulaire
Derme acellulaire
Matériaux biocompatibles
Cellules souches
Macrophages
Engenharia Tecidual
Transplantes
Derme Acelular
Biomateriais
Células-Tronco
Macrófagos
title_short Decellularized extracellular matrix: the role of this complex biomaterial in regeneration
title_full Decellularized extracellular matrix: the role of this complex biomaterial in regeneration
title_fullStr Decellularized extracellular matrix: the role of this complex biomaterial in regeneration
title_full_unstemmed Decellularized extracellular matrix: the role of this complex biomaterial in regeneration
title_sort Decellularized extracellular matrix: the role of this complex biomaterial in regeneration
author Paula, André Guilherme Portela de
author_facet Paula, André Guilherme Portela de
Lima, Jordana Dinorá de
Bastos, Thais Sibioni Berti
Czaikovski, Andressa Pacheco
Luz, Rebeca Bosso dos Santos
Yuasa, Bruna Sadae
Smanioto, Caio Cesar Souza
Robert, Anny Waloski
Braga, Tárcio Teodoro
author_role author
author2 Lima, Jordana Dinorá de
Bastos, Thais Sibioni Berti
Czaikovski, Andressa Pacheco
Luz, Rebeca Bosso dos Santos
Yuasa, Bruna Sadae
Smanioto, Caio Cesar Souza
Robert, Anny Waloski
Braga, Tárcio Teodoro
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Paula, André Guilherme Portela de
Lima, Jordana Dinorá de
Bastos, Thais Sibioni Berti
Czaikovski, Andressa Pacheco
Luz, Rebeca Bosso dos Santos
Yuasa, Bruna Sadae
Smanioto, Caio Cesar Souza
Robert, Anny Waloski
Braga, Tárcio Teodoro
dc.subject.en.none.fl_str_mv Tissue Engineering
Transplants
Decellularized Tissues
Biocompatible Materials
Stem Cells
Macrophages
topic Tissue Engineering
Transplants
Decellularized Tissues
Biocompatible Materials
Stem Cells
Macrophages
Ingeniería de Tejidos
Trasplantes
Acellular Dermis
Materiales Biocompatibles
Células Madre
Ingénierie tissulaire
Derme acellulaire
Matériaux biocompatibles
Cellules souches
Macrophages
Engenharia Tecidual
Transplantes
Derme Acelular
Biomateriais
Células-Tronco
Macrófagos
dc.subject.es.none.fl_str_mv Ingeniería de Tejidos
Trasplantes
Acellular Dermis
Materiales Biocompatibles
Células Madre
dc.subject.fr.none.fl_str_mv Ingénierie tissulaire
Derme acellulaire
Matériaux biocompatibles
Cellules souches
Macrophages
dc.subject.decs.none.fl_str_mv Engenharia Tecidual
Transplantes
Derme Acelular
Biomateriais
Células-Tronco
Macrófagos
description Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-07-21T17:16:56Z
dc.date.available.fl_str_mv 2023-07-21T17:16:56Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PAULA, André Guilherme Portela de et al. Decellularized extracellular matrix: the role of this complex biomaterial in regeneration. ACS Omega, v. 8, n. 25, p. 22256-22267, Jun. 2023.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/59716
dc.identifier.issn.none.fl_str_mv 2470-1343
dc.identifier.doi.none.fl_str_mv 10.1021/acsomega.2c06216
identifier_str_mv PAULA, André Guilherme Portela de et al. Decellularized extracellular matrix: the role of this complex biomaterial in regeneration. ACS Omega, v. 8, n. 25, p. 22256-22267, Jun. 2023.
2470-1343
10.1021/acsomega.2c06216
url https://arca.fiocruz.br/handle/icict/59716
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://arca.fiocruz.br/bitstreams/beea8a15-537c-4a70-a7e7-8486c585ef0d/download
https://arca.fiocruz.br/bitstreams/7363a86f-b67d-4b75-88a6-ebe53d67f2b2/download
https://arca.fiocruz.br/bitstreams/08d542e9-3bfd-41ea-aa31-9a5a46e3e11a/download
https://arca.fiocruz.br/bitstreams/b63863f4-5dbc-4332-9b2e-8f0958fc74c0/download
bitstream.checksum.fl_str_mv 8dabde7462714eeea51e993cc0c0a943
5a560609d32a3863062d77ff32785d58
f0eb5d6d5915851bad6a7b81e2bc3ca1
552aa19be20e10653b6e567b4eeac7cf
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1839715901100785664

Similar Items