Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones

Detalhes bibliográficos
Autor(a) principal: Vieira, Lígia Maria M.
Data de Publicação: 2009
Outros Autores: Almeida, Mauro V. de, Lourenço, Maria Cristina S., Bezerra, Flávio Augusto F. M., Fontes, Ana Paula S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.ejmech.2009.05.001
Texto Completo: https://arca.fiocruz.br/handle/icict/38935
Resumo: 2021-01-02
id CRUZ_49b9771bd0214018bff39cde94c38a4f
oai_identifier_str oai:arca.fiocruz.br:icict/38935
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Vieira, Lígia Maria M.Almeida, Mauro V. deLourenço, Maria Cristina S.Bezerra, Flávio Augusto F. M.Fontes, Ana Paula S.2020-01-02T13:06:36Z2020-01-02T13:06:36Z2009VIEIRA, Lígia Maria M. et al. Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones. European Journal of Medicinal Chemistry, v. 44, p. 4107-4111, 2009.0223-5234https://arca.fiocruz.br/handle/icict/3893510.1016/j.ejmech.2009.05.0011768-3254engElsevierSynthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolonesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2021-01-02Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal de Juiz de Fora. Departamento de Química. Juiz de Fora, MG, Brasil.The fluoroquinolones are an important family of synthetic antimicrobial agents being clinically used overthe past thirty years. In addition, some fluoroquinolones have been used in the development of anti-cancer drugs, and others have demonstrated anti-HIV activity. Furthermore, there has been someadditional work investigating the effect of metal ions on biological activity.Aiming to obtain novel palladium(II) and platinum(II) complexes that exhibit biological activity, we havesynthesized complexes using fluoroquinolones (ciprofloxacin, levofloxacin, ofloxacin, sparfloxacin, andgatifloxacin) as ligands. The compounds were characterized using IR and NMR spectroscopy, thermog-ravimetric and elemental analyses.The complexes show activity againstMycobacterium tuberculosisstrain H37Rv. The minimal inhibitoryconcentration (MIC) of the complexes was determined.FluoroquinolonePalladium complexPlatinum complexAntitubercularinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://arca.fiocruz.br/bitstreams/3556c5ed-3600-4562-8e09-5470bfef81c0/download8a4605be74aa9ea9d79846c1fba20a33MD51falseAnonymousREADORIGINALve_Vieira_Lígia_etal_INI_2009.pdfve_Vieira_Lígia_etal_INI_2009.pdfapplication/pdf212398https://arca.fiocruz.br/bitstreams/40500081-be4f-44ee-94d4-736e82b90d4a/downloadc9516e072f020beeb5b21a4aa5439380MD52trueAnonymousREAD2021-01-02TEXTve_Vieira_Lígia_etal_INI_2009.pdf.txtve_Vieira_Lígia_etal_INI_2009.pdf.txtExtracted texttext/plain25319https://arca.fiocruz.br/bitstreams/0fe60c66-cfc8-467f-b71b-82ac6b15ee3c/downloade25baec895fd42c02a936a166ecdda7fMD55falseAnonymousREAD2021-01-02THUMBNAILve_Vieira_Lígia_etal_INI_2009.pdf.jpgve_Vieira_Lígia_etal_INI_2009.pdf.jpgGenerated Thumbnailimage/jpeg6319https://arca.fiocruz.br/bitstreams/b82b53f4-0357-4a8d-9c9f-7d9c05d9b95b/download0b6a2d07d89c28e07a9788d7be63c606MD56falseAnonymousREAD2021-01-02icict/389352025-07-29 22:16:58.025open.accessoai:arca.fiocruz.br:icict/38935https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T01:16:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)falseTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=
dc.title.none.fl_str_mv Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones
title Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones
spellingShingle Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones
Vieira, Lígia Maria M.
Fluoroquinolone
Palladium complex
Platinum complex
Antitubercular
title_short Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones
title_full Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones
title_fullStr Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones
title_full_unstemmed Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones
title_sort Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones
author Vieira, Lígia Maria M.
author_facet Vieira, Lígia Maria M.
Almeida, Mauro V. de
Lourenço, Maria Cristina S.
Bezerra, Flávio Augusto F. M.
Fontes, Ana Paula S.
author_role author
author2 Almeida, Mauro V. de
Lourenço, Maria Cristina S.
Bezerra, Flávio Augusto F. M.
Fontes, Ana Paula S.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Vieira, Lígia Maria M.
Almeida, Mauro V. de
Lourenço, Maria Cristina S.
Bezerra, Flávio Augusto F. M.
Fontes, Ana Paula S.
dc.subject.en.none.fl_str_mv Fluoroquinolone
Palladium complex
Platinum complex
Antitubercular
topic Fluoroquinolone
Palladium complex
Platinum complex
Antitubercular
description 2021-01-02
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2020-01-02T13:06:36Z
dc.date.available.fl_str_mv 2020-01-02T13:06:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VIEIRA, Lígia Maria M. et al. Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones. European Journal of Medicinal Chemistry, v. 44, p. 4107-4111, 2009.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/38935
dc.identifier.issn.none.fl_str_mv 0223-5234
dc.identifier.doi.none.fl_str_mv 10.1016/j.ejmech.2009.05.001
dc.identifier.eissn.none.fl_str_mv 1768-3254
identifier_str_mv VIEIRA, Lígia Maria M. et al. Synthesis and antitubercular activity of palladium and platinum complexes with fluoroquinolones. European Journal of Medicinal Chemistry, v. 44, p. 4107-4111, 2009.
0223-5234
10.1016/j.ejmech.2009.05.001
1768-3254
url https://arca.fiocruz.br/handle/icict/38935
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://arca.fiocruz.br/bitstreams/3556c5ed-3600-4562-8e09-5470bfef81c0/download
https://arca.fiocruz.br/bitstreams/40500081-be4f-44ee-94d4-736e82b90d4a/download
https://arca.fiocruz.br/bitstreams/0fe60c66-cfc8-467f-b71b-82ac6b15ee3c/download
https://arca.fiocruz.br/bitstreams/b82b53f4-0357-4a8d-9c9f-7d9c05d9b95b/download
bitstream.checksum.fl_str_mv 8a4605be74aa9ea9d79846c1fba20a33
c9516e072f020beeb5b21a4aa5439380
e25baec895fd42c02a936a166ecdda7f
0b6a2d07d89c28e07a9788d7be63c606
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1839716111912796160

Registros relacionados