Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies.

Bibliographic Details
Main Author: Quirino, Ângela
Publication Date: 2024
Other Authors: Marascio, Nadia, Branda, Francesco, Ciccozzi, Alessandra, Romano, Chiara, Locci, Chiara, Azzena, Ilenia, Pascale, Noemi, Pavia, Grazia, Matera, Giovanni, Casu, Marco, Sanna, Daria, Giovanetti, Marta, Ceccarelli, Giancarlo, Loro, Pierfrancesco Alaimo di, Ciccozzi, Massimo, Scarpa, Fabio, Maruotti, Antonello
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.3390/pathogens13090766.
Download full: https://arca.fiocruz.br/handle/icict/67873
Summary: "Magna Græcia" University of Catanzaro "Renato Dulbecco" Teaching Hospital. Unit of Clinical Microbiology, Department of Health Sciences. Catanzaro, Italy.
id CRUZ_3204851c64aefe8d7f12b1f9ea4ba7f5
oai_identifier_str oai:arca.fiocruz.br:icict/67873
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Quirino, ÂngelaMarascio, NadiaBranda, FrancescoCiccozzi, AlessandraRomano, ChiaraLocci, ChiaraAzzena, IleniaPascale, NoemiPavia, GraziaMatera, GiovanniCasu, MarcoSanna, DariaGiovanetti, MartaCeccarelli, GiancarloLoro, Pierfrancesco Alaimo diCiccozzi, MassimoScarpa, FabioMaruotti, Antonello2025-01-06T16:46:21Z2025-01-06T16:46:21Z2024QUIRINO, Ângela et al. Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies. Pathogens, v. 13, n. 9, 766, 2024.2076-0817https://arca.fiocruz.br/handle/icict/6787310.3390/pathogens13090766.engMPDIViral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article"Magna Græcia" University of Catanzaro "Renato Dulbecco" Teaching Hospital. Unit of Clinical Microbiology, Department of Health Sciences. Catanzaro, Italy."Magna Græcia" University of Catanzaro "Renato Dulbecco" Teaching Hospital. Unit of Clinical Microbiology, Department of Health Sciences. Catanzaro, Italy.Università Campus Bio-Medico di Roma. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.University of Sassari. Department of Biomedical Sciences. Sassari, Italy.Università Campus Bio-Medico di Roma. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.University of Sassari. Department of Biomedical Sciences. Sassari, Italy. / University of Sassari. Department of Veterinary Medicine. Sassari, Italy.University of Sassari. Department of Veterinary Medicine. Sassari, ItalyUniversity of Sassari. Department of Veterinary Medicine. Sassari, Italy. / University of Sassari. Department of Chemical Physical Mathematical and Natural Sciences. Sassari, Italy."Magna Græcia" University of Catanzaro "Renato Dulbecco" Teaching Hospital. Unit of Clinical Microbiology, Department of Health Sciences. Catanzaro, Italy."Magna Græcia" University of Catanzaro "Renato Dulbecco" Teaching Hospital. Unit of Clinical Microbiology, Department of Health Sciences. Catanzaro, Italy.University of Sassari. Department of Veterinary Medicine. Sassari, Italy.University of Sassari. Department of Biomedical Sciences. Sassari, Italy.Università Campus Bio-Medico di Roma. Department of Sciences and Technologies for Sustainable Development and One Health. Rome, Italy / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. / Climate Amplified Diseases and Epidemics. Brasilia, DF, Brasil.Sapienza University of Rome. University Hospital Policlinico Umberto I. Department of Public Health and Infectious Diseases. Rome, Italy.Libera Università Maria Ss Assunta. Department GEPLI. Rome, Italy.Università Campus Bio-Medico di Roma. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.University of Sassari. Department of Biomedical Sciences. Sassari, Italy.Libera Università Maria Ss Assunta. Department GEPLI. Rome, Italy.Viral hepatitis is a major cause of liver illness worldwide. Despite advances in the understanding of these infections, the pathogenesis of hepatitis remains a complex process driven by intricate interactions between hepatitis viruses and host cells at the molecular level. This paper will examine in detail the dynamics of these host-pathogen interactions, highlighting the key mechanisms that regulate virus entry into the hepatocyte, their replication, evasion of immune responses, and induction of hepatocellular damage. The unique strategies employed by different hepatitis viruses, such as hepatitis B, C, D, and E viruses, to exploit metabolic and cell signaling pathways to their advantage will be discussed. At the same time, the innate and adaptive immune responses put in place by the host to counter viral infection will be analyzed. Special attention will be paid to genetic, epigenetic, and environmental factors that modulate individual susceptibility to different forms of viral hepatitis. In addition, this work will highlight the latest findings on the mechanisms of viral persistence leading to the chronic hepatitis state and the potential implications for the development of new therapeutic strategies. Fully understanding the complex host-pathogen interactions in viral hepatitis is crucial to identifying new therapeutic targets, developing more effective approaches for treatment, and shedding light on the mechanisms underlying progression to more advanced stages of liver damage.Host–pathogen interactionsImmune evasion mechanismsTherapeutic strategiesViral hepatitisViral persistenceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/d7bcecc4-4502-4189-bed3-c71b7629b630/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALpathogens-13-00766.pdfpathogens-13-00766.pdfapplication/pdf1075887https://arca.fiocruz.br/bitstreams/96ea0f23-54d8-41ff-bdd4-1cec36d15fe6/downloadc4595731d72fe68cdfa6a9ba550cb1fbMD52trueAnonymousREADTEXTpathogens-13-00766.pdf.txtpathogens-13-00766.pdf.txtExtracted texttext/plain100388https://arca.fiocruz.br/bitstreams/f2d58acd-8b8b-420c-bda7-65b90df6f4fb/download579552182f7eb4445fd3a7d6308c8839MD55falseAnonymousREADTHUMBNAILpathogens-13-00766.pdf.jpgpathogens-13-00766.pdf.jpgGenerated Thumbnailimage/jpeg5608https://arca.fiocruz.br/bitstreams/b9029b41-e068-4e3e-9d8d-1ffbf8415023/downloadc98eb8800c60ab351cbcd841cd05a58cMD56falseAnonymousREADicict/678732025-07-30 01:39:30.927open.accessoai:arca.fiocruz.br:icict/67873https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T04:39:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
dc.title.none.fl_str_mv Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies.
title Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies.
spellingShingle Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies.
Quirino, Ângela
Host–pathogen interactions
Immune evasion mechanisms
Therapeutic strategies
Viral hepatitis
Viral persistence
title_short Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies.
title_full Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies.
title_fullStr Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies.
title_full_unstemmed Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies.
title_sort Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies.
author Quirino, Ângela
author_facet Quirino, Ângela
Marascio, Nadia
Branda, Francesco
Ciccozzi, Alessandra
Romano, Chiara
Locci, Chiara
Azzena, Ilenia
Pascale, Noemi
Pavia, Grazia
Matera, Giovanni
Casu, Marco
Sanna, Daria
Giovanetti, Marta
Ceccarelli, Giancarlo
Loro, Pierfrancesco Alaimo di
Ciccozzi, Massimo
Scarpa, Fabio
Maruotti, Antonello
author_role author
author2 Marascio, Nadia
Branda, Francesco
Ciccozzi, Alessandra
Romano, Chiara
Locci, Chiara
Azzena, Ilenia
Pascale, Noemi
Pavia, Grazia
Matera, Giovanni
Casu, Marco
Sanna, Daria
Giovanetti, Marta
Ceccarelli, Giancarlo
Loro, Pierfrancesco Alaimo di
Ciccozzi, Massimo
Scarpa, Fabio
Maruotti, Antonello
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Quirino, Ângela
Marascio, Nadia
Branda, Francesco
Ciccozzi, Alessandra
Romano, Chiara
Locci, Chiara
Azzena, Ilenia
Pascale, Noemi
Pavia, Grazia
Matera, Giovanni
Casu, Marco
Sanna, Daria
Giovanetti, Marta
Ceccarelli, Giancarlo
Loro, Pierfrancesco Alaimo di
Ciccozzi, Massimo
Scarpa, Fabio
Maruotti, Antonello
dc.subject.en.none.fl_str_mv Host–pathogen interactions
Immune evasion mechanisms
Therapeutic strategies
Viral hepatitis
Viral persistence
topic Host–pathogen interactions
Immune evasion mechanisms
Therapeutic strategies
Viral hepatitis
Viral persistence
description "Magna Græcia" University of Catanzaro "Renato Dulbecco" Teaching Hospital. Unit of Clinical Microbiology, Department of Health Sciences. Catanzaro, Italy.
publishDate 2024
dc.date.issued.fl_str_mv 2024
dc.date.accessioned.fl_str_mv 2025-01-06T16:46:21Z
dc.date.available.fl_str_mv 2025-01-06T16:46:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv QUIRINO, Ângela et al. Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies. Pathogens, v. 13, n. 9, 766, 2024.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/67873
dc.identifier.issn.none.fl_str_mv 2076-0817
dc.identifier.doi.none.fl_str_mv 10.3390/pathogens13090766.
identifier_str_mv QUIRINO, Ângela et al. Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies. Pathogens, v. 13, n. 9, 766, 2024.
2076-0817
10.3390/pathogens13090766.
url https://arca.fiocruz.br/handle/icict/67873
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MPDI
publisher.none.fl_str_mv MPDI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://arca.fiocruz.br/bitstreams/d7bcecc4-4502-4189-bed3-c71b7629b630/download
https://arca.fiocruz.br/bitstreams/96ea0f23-54d8-41ff-bdd4-1cec36d15fe6/download
https://arca.fiocruz.br/bitstreams/f2d58acd-8b8b-420c-bda7-65b90df6f4fb/download
https://arca.fiocruz.br/bitstreams/b9029b41-e068-4e3e-9d8d-1ffbf8415023/download
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
c4595731d72fe68cdfa6a9ba550cb1fb
579552182f7eb4445fd3a7d6308c8839
c98eb8800c60ab351cbcd841cd05a58c
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1839716389896585216

Similar Items