Comparison of two databases to detect potential drug-drug interactions between prescriptions of HIV/AIDS patients in critical care

Bibliographic Details
Main Author: Ramos, G. V.
Publication Date: 2015
Other Authors: Guaraldo, L., Japiassú, A. M., Bozza, Fernando A.
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1111/jcpt.12222
Download full: https://arca.fiocruz.br/handle/icict/34910
Summary: 2020-08-20
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spelling Ramos, G. V.Guaraldo, L.Japiassú, A. M.Bozza, Fernando A.2019-08-20T14:59:01Z2019-08-20T14:59:01Z2015RAMOS, G. V. et al. Comparison of two databases to detect potential drug-drug interactions betweenprescriptions of HIV/AIDS patients in critical care. Journal of Clinical Pharmacy and Therapeutics, v. 40, p. 63-67, 2015.0269-4727https://arca.fiocruz.br/handle/icict/3491010.1111/jcpt.122221365-2710engWilleyComparison of two databases to detect potential drug-drug interactions between prescriptions of HIV/AIDS patients in critical careinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-08-20Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.What is known and objective: Adverse drug events (ADE),common and underestimated in ICU patients, have direct consequences on length of stay, mortality and hospital costs. Critically ill patients with HIV/AIDS are at a high risk of ADE because of their need for multiple drug therapies. ADE can be prevented, especially by the identification of potentially harmful drug-drug interactions (DDIs). Electronic databases are useful tools for the investigation of DDIs to avoid potential ADEs, thereby increasing patient safety. The purpose of this study was to compare the classification and severity rating of potential adverse drug interactions seen in the prescriptions for patients with HIV/AIDS in two databases, one with free access (Drugs.comTM) and another requiring payment for access (Mi-cromedexâ). Methods: A cross-sectional retrospective study of the prescriptions issued for 40 ICU HIV/AIDS patients on mechanical ventilation, admitted for more than 48 h, in a referral hospital for infectious diseases in Rio de Janeiro, Brazil, was undertaken. One prescription was reviewed each week for each patient from the second day after admission. A list of all drug–drug interactions was generated for each patient using the two drug-drug interactions databases. The weighted kappa index was estimated to assess the agreement between the classifications of DDIs identified by both databases and qualitative assessment made of any discordant classification of recorded drug-drug interactions. Results and discussion: Of the 106 prescriptions analysed, Micromedex and Drugs.com identified 347 and 615 potential DDIs, respectively. A predominance of moderate interactions and pharmacokinetic interactions was observed. The agreement between the databases regarding the severity rating was only 68.3%. The weighted kappa of 0.44 is considered moderate. Better agreement (82.4%) was observed in the classification of mechanism of interaction, with a weighted kappa of 0.61. What is new and Conclusion: DDIs are common between the prescriptions of patients with HIV/AIDS admitted to the ICU. Although both databases were able to identify the clinically relevant DDIs, we observed a significant discrepancy in the classification of the severity of DDIs in the two bases. The free access database could serve as an alternative to the identificationof DDIs in resource-limited settings; however, there is a need for better evidence-based assessments for your use on clinical management of more serious DDIs.AIDSCritically illDrug prescriptionsDrug-drug interactionsIntensive care unitPharmacovigilance03 Saúde e Bem-Estarinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://arca.fiocruz.br/bitstreams/6b071b2e-0f02-4451-856c-416af2b1ee96/download8a4605be74aa9ea9d79846c1fba20a33MD51falseAnonymousREADORIGINALve_Ramos_G_etal_INI_2015.pdfve_Ramos_G_etal_INI_2015.pdfapplication/pdf654063https://arca.fiocruz.br/bitstreams/7cfffddb-ea83-4e10-ace4-a479a1b1df8a/downloadd3ca216a64629e434383695167a016c0MD52trueAnonymousREAD2020-08-20TEXTve_Ramos_G_etal_INI_2015.pdf.txtve_Ramos_G_etal_INI_2015.pdf.txtExtracted texttext/plain23404https://arca.fiocruz.br/bitstreams/d41f7aa4-141f-495d-9d13-68d698f3b2bc/download9e1b9ccc366030f5a480d2f34b6a3649MD57falseAnonymousREAD2020-08-20THUMBNAILve_Ramos_G_etal_INI_2015.pdf.jpgve_Ramos_G_etal_INI_2015.pdf.jpgGenerated Thumbnailimage/jpeg6113https://arca.fiocruz.br/bitstreams/ed777ff4-1a4d-4671-9d9f-35f263c64e4a/download6e89f7c9879c99654a6fc6ab5df30412MD58falseAnonymousREAD2020-08-20icict/349102025-08-03 15:46:05.028open.accessoai:arca.fiocruz.br:icict/34910https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-08-03T18:46:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
dc.title.none.fl_str_mv Comparison of two databases to detect potential drug-drug interactions between prescriptions of HIV/AIDS patients in critical care
title Comparison of two databases to detect potential drug-drug interactions between prescriptions of HIV/AIDS patients in critical care
spellingShingle Comparison of two databases to detect potential drug-drug interactions between prescriptions of HIV/AIDS patients in critical care
Ramos, G. V.
AIDS
Critically ill
Drug prescriptions
Drug-drug interactions
Intensive care unit
Pharmacovigilance
03 Saúde e Bem-Estar
title_short Comparison of two databases to detect potential drug-drug interactions between prescriptions of HIV/AIDS patients in critical care
title_full Comparison of two databases to detect potential drug-drug interactions between prescriptions of HIV/AIDS patients in critical care
title_fullStr Comparison of two databases to detect potential drug-drug interactions between prescriptions of HIV/AIDS patients in critical care
title_full_unstemmed Comparison of two databases to detect potential drug-drug interactions between prescriptions of HIV/AIDS patients in critical care
title_sort Comparison of two databases to detect potential drug-drug interactions between prescriptions of HIV/AIDS patients in critical care
author Ramos, G. V.
author_facet Ramos, G. V.
Guaraldo, L.
Japiassú, A. M.
Bozza, Fernando A.
author_role author
author2 Guaraldo, L.
Japiassú, A. M.
Bozza, Fernando A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Ramos, G. V.
Guaraldo, L.
Japiassú, A. M.
Bozza, Fernando A.
dc.subject.en.none.fl_str_mv AIDS
Critically ill
Drug prescriptions
Drug-drug interactions
Intensive care unit
Pharmacovigilance
topic AIDS
Critically ill
Drug prescriptions
Drug-drug interactions
Intensive care unit
Pharmacovigilance
03 Saúde e Bem-Estar
dc.subject.ods.none.fl_str_mv 03 Saúde e Bem-Estar
description 2020-08-20
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-08-20T14:59:01Z
dc.date.available.fl_str_mv 2019-08-20T14:59:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RAMOS, G. V. et al. Comparison of two databases to detect potential drug-drug interactions betweenprescriptions of HIV/AIDS patients in critical care. Journal of Clinical Pharmacy and Therapeutics, v. 40, p. 63-67, 2015.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/34910
dc.identifier.issn.none.fl_str_mv 0269-4727
dc.identifier.doi.none.fl_str_mv 10.1111/jcpt.12222
dc.identifier.eissn.none.fl_str_mv 1365-2710
identifier_str_mv RAMOS, G. V. et al. Comparison of two databases to detect potential drug-drug interactions betweenprescriptions of HIV/AIDS patients in critical care. Journal of Clinical Pharmacy and Therapeutics, v. 40, p. 63-67, 2015.
0269-4727
10.1111/jcpt.12222
1365-2710
url https://arca.fiocruz.br/handle/icict/34910
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Willey
publisher.none.fl_str_mv Willey
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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