Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?

Bibliographic Details
Main Author: Arruda, Valder Roberval
Publication Date: 1998
Other Authors: Grignolli, Carlos e, Gonçalves, Marilda de Souza, Soares, Manoel C., Menezes, Raimundo, Saad, Sara Teresinha Ollala, Costa, Fernando Ferreira
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://arca.fiocruz.br/handle/icict/19338
Summary: Marilda de Souza Gonçalves “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Arruda, Valder RobervalGrignolli, Carlos eGonçalves, Marilda de SouzaSoares, Manoel C.Menezes, RaimundoSaad, Sara Teresinha OllalaCosta, Fernando Ferreira2017-06-07T16:07:29Z2017-06-07T16:07:29Z1998ARRUDA, V. R. et al. Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis? Clinical Genetics, v. 54, n. 3, p. 210-214, 1998.0009-9163https://arca.fiocruz.br/handle/icict/19338Marilda de Souza Gonçalves “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.State Universtty of Campinas. Hematology-Hernotherapy Center. Campinas, SP, BrasilState Universtty of Campinas. Hematology-Hernotherapy Center. Campinas, SP, BrasilFederal University of Bahia. Saivador, BA, BrasilEvandro Chagas Institute. Belélm, PA, BrasilEvandro Chagas Institute. Belélm, PA, BrasilState Universtty of Campinas. Hematology-Hernotherapy Center. Campinas, SP, BrasilState Universtty of Campinas. Hematology-Hernotherapy Center. Campinas, SP, BrasilEnvironmental related diseases due to occupational carcinogens and toxic substances are a serious problem particularly in developing countries. The glutathione S-transferase system is fundamental for the detoxification of numerous carcinogens and mutagens. The individual inherited susceptibility to chemical carcinogenesis due to glutathione S-transferase mu (GSTMl) and theta (GSTTl) varies significantly among distinct ethnic groups. In this study we determined the prevalence of the null genotype of the GSTMl and GSTTl genes among individuals from three distinct Brazilian racial groups using a multiplex- PCR methodology. The results showed that the highest prevalence of the null genotype for the GSTMl occurred among Caucasians (55%, allele frequency = 0.74), followed by 33% among Brazilian Black subjects (allele frequency = 0.57). and 20% among Amazonian Indians (allele frequency = 0.45). For GSTTl a homogenous distribution of the null genotype was found among Caucasian and African descendants (18.5 and 19% homozygotes, respectively, allele. frequency = 0.43). with a lower prevalence among Amazonian Indians (1 1% of homozygotes, a!lele frequency = 0.34). Whether the deficiency of the GST system contributes to a predisposition to environmental related carcinogenesis in I specific popuiations in Brazil remains to be determined.engWilleyDNAGlutationa S transferasePCRMutaçãoDNA analyslsGlutathione S transferase muGlutathione S transferase mu theta genePCRMutationDNAGlutationa S transferasePCRCarcinogêneseMutaçãoPrevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/5d333f86-3538-4391-a72f-cbd7d05220f1/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALArruda VR Prevalence of homozygosity.....pdfArruda VR Prevalence of homozygosity.....pdfapplication/pdf546897https://arca.fiocruz.br/bitstreams/0c13c2fe-ef39-409b-9a56-375475b8952e/download2d475ef7e94a0a8d19354493a1c6c71dMD52trueAnonymousREADTEXTArruda VR Prevalence of homozygosity.....pdf.txtArruda VR Prevalence of homozygosity.....pdf.txtExtracted texttext/plain21487https://arca.fiocruz.br/bitstreams/c378f73b-84f8-42ed-9f7e-b294a1c25617/download0d21884cbbc2377690c5e194b120fa0cMD55falseAnonymousREADTHUMBNAILArruda VR Prevalence of homozygosity.....pdf.jpgArruda VR Prevalence of homozygosity.....pdf.jpgGenerated Thumbnailimage/jpeg6666https://arca.fiocruz.br/bitstreams/ae38459d-0427-4a3a-9478-4298a795a74d/download01c737ef7ea0d878a06598b74e3c9660MD56falseAnonymousREADicict/193382025-08-03 15:46:37.487open.accessoai:arca.fiocruz.br:icict/19338https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-08-03T18:46:37Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?
title Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?
spellingShingle Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?
Arruda, Valder Roberval
DNA
Glutationa S transferase
PCR
Mutação
DNA analysls
Glutathione S transferase mu
Glutathione S transferase mu theta gene
PCR
Mutation
DNA
Glutationa S transferase
PCR
Carcinogênese
Mutação
title_short Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?
title_full Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?
title_fullStr Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?
title_full_unstemmed Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?
title_sort Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis?
author Arruda, Valder Roberval
author_facet Arruda, Valder Roberval
Grignolli, Carlos e
Gonçalves, Marilda de Souza
Soares, Manoel C.
Menezes, Raimundo
Saad, Sara Teresinha Ollala
Costa, Fernando Ferreira
author_role author
author2 Grignolli, Carlos e
Gonçalves, Marilda de Souza
Soares, Manoel C.
Menezes, Raimundo
Saad, Sara Teresinha Ollala
Costa, Fernando Ferreira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Arruda, Valder Roberval
Grignolli, Carlos e
Gonçalves, Marilda de Souza
Soares, Manoel C.
Menezes, Raimundo
Saad, Sara Teresinha Ollala
Costa, Fernando Ferreira
dc.subject.other.none.fl_str_mv DNA
Glutationa S transferase
PCR
Mutação
topic DNA
Glutationa S transferase
PCR
Mutação
DNA analysls
Glutathione S transferase mu
Glutathione S transferase mu theta gene
PCR
Mutation
DNA
Glutationa S transferase
PCR
Carcinogênese
Mutação
dc.subject.en.none.fl_str_mv DNA analysls
Glutathione S transferase mu
Glutathione S transferase mu theta gene
PCR
Mutation
dc.subject.decs.none.fl_str_mv DNA
Glutationa S transferase
PCR
Carcinogênese
Mutação
description Marilda de Souza Gonçalves “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2017-06-07T16:07:29Z
dc.date.available.fl_str_mv 2017-06-07T16:07:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARRUDA, V. R. et al. Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis? Clinical Genetics, v. 54, n. 3, p. 210-214, 1998.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/19338
dc.identifier.issn.none.fl_str_mv 0009-9163
identifier_str_mv ARRUDA, V. R. et al. Prevalence of homozygosity for the deleted alleles of glutathione S-transferase mu (GSTM1) and theta (GSTT1) among distinct ethnic groups from Brazil: relevance to environmental carcinogenesis? Clinical Genetics, v. 54, n. 3, p. 210-214, 1998.
0009-9163
url https://arca.fiocruz.br/handle/icict/19338
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Willey
publisher.none.fl_str_mv Willey
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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