Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B

Bibliographic Details
Main Author: Machado, Paulo Roberto Lima
Publication Date: 2015
Other Authors: Rosa, Maria Elisa Alves, Guimarães, Luís Henrique Santos, Prates, Fernanda Ventim de Oliveira, Queiroz, Adriano, Schriefer, Albert, Carvalho Filho, Edgar Marcelino
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1093/cid/civ416
Download full: https://arca.fiocruz.br/handle/icict/20542
Summary: Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Machado, Paulo Roberto LimaRosa, Maria Elisa AlvesGuimarães, Luís Henrique SantosPrates, Fernanda Ventim de OliveiraQueiroz, AdrianoSchriefer, AlbertCarvalho Filho, Edgar Marcelino2017-08-08T17:20:42Z2017-08-08T17:20:42Z2015MACHADO, P. R. L. et al. Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B. Clinical Infectious Diseases, v. 61, p. 945-949, 2015.1058-4838https://arca.fiocruz.br/handle/icict/2054210.1093/cid/civ416Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Ministry of Health of Brazil (MS) and the National Council of Scientific and Technological Development (CNPq) [Edital MS-SCIET-DECIT/CNPq No 69/2010].Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, BrasilDisseminated leishmaniasis (DL) is a severe and emerging form of American tegumentary leishmaniasis, associated primarily with infection by Leishmania brasiliensis. DL is defined by the presence of ≥10 mixed-type lesions such as inflammatory papules and ulcers, located in ≥2 body parts. Most patients have hundreds of lesions all over the body, and mucosal involvement is detected in up to 44% of cases. DL is a difficult to cure disease and pentavalent antimony (Sb(v)) is used as standard treatment, its highest dosage being 20 mg/kg/day, for 30 days. However, less than 25% of DL cases will be cured after standard therapy, and the majority of cases will require more than one course of Sb(v) for a cure. In this context, new therapies are needed that offer a higher cure rate and a better safety profile, with convenience in drug administration. Methods. We have evaluated liposomal amphotericin B in 20 patients with DL in an open clinical trial. The total dose ranged from 17 to 37 mg/kg, used in 7 to 14 days of treatment. Results. Cure rate at 3 months after therapy was 70%. One relapse was documented 4 months after treatment, producing a final cure rate of 65%. Although liposomal amphotericin B was considered well tolerated, mild adverse events were documented in 75% of the patients. Conclusions. Liposomal amphotericin B is an effective therapy for DL, with a higher final cure rate of 75% observed when used in a total dose above 30 mg/kg.engOxfor University PressLeishmaniose tegumentar americanaLeishmanioseAnfotericina BAmerican tegumentary leishmaniasisDisseminated leishmaniasisLiposomal amphotericin BTreatment of Disseminated Leishmaniasis With Liposomal Amphotericin Binfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/d4afa70d-ded4-41b2-a869-2e20f8e948f9/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALMachado PRL Treatment of dissemination....pdfMachado PRL Treatment of dissemination....pdfapplication/pdf168180https://arca.fiocruz.br/bitstreams/5148c8e8-59d3-4386-ae7c-96fa3bf0fd7b/downloadd159a2621cf974ef7a63d81b96cebca5MD52trueAnonymousREADTEXTMachado PRL Treatment of dissemination....pdf.txtMachado PRL Treatment of dissemination....pdf.txtExtracted texttext/plain26648https://arca.fiocruz.br/bitstreams/d8ee2c45-7867-4241-8754-f08dbefe6af6/download36205aa523051e5969e3b36e469b3f55MD57falseAnonymousREADTHUMBNAILMachado PRL Treatment of dissemination....pdf.jpgMachado PRL Treatment of dissemination....pdf.jpgGenerated Thumbnailimage/jpeg5667https://arca.fiocruz.br/bitstreams/aea2f043-103f-4829-b2c1-0e44c984620d/download1bc3a01baa79eef9ef70afebaa82066cMD58falseAnonymousREADicict/205422025-07-29 19:26:51.888open.accessoai:arca.fiocruz.br:icict/20542https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T22:26:51Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.none.fl_str_mv Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B
title Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B
spellingShingle Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B
Machado, Paulo Roberto Lima
Leishmaniose tegumentar americana
Leishmaniose
Anfotericina B
American tegumentary leishmaniasis
Disseminated leishmaniasis
Liposomal amphotericin B
title_short Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B
title_full Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B
title_fullStr Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B
title_full_unstemmed Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B
title_sort Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B
author Machado, Paulo Roberto Lima
author_facet Machado, Paulo Roberto Lima
Rosa, Maria Elisa Alves
Guimarães, Luís Henrique Santos
Prates, Fernanda Ventim de Oliveira
Queiroz, Adriano
Schriefer, Albert
Carvalho Filho, Edgar Marcelino
author_role author
author2 Rosa, Maria Elisa Alves
Guimarães, Luís Henrique Santos
Prates, Fernanda Ventim de Oliveira
Queiroz, Adriano
Schriefer, Albert
Carvalho Filho, Edgar Marcelino
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Machado, Paulo Roberto Lima
Rosa, Maria Elisa Alves
Guimarães, Luís Henrique Santos
Prates, Fernanda Ventim de Oliveira
Queiroz, Adriano
Schriefer, Albert
Carvalho Filho, Edgar Marcelino
dc.subject.other.none.fl_str_mv Leishmaniose tegumentar americana
Leishmaniose
Anfotericina B
topic Leishmaniose tegumentar americana
Leishmaniose
Anfotericina B
American tegumentary leishmaniasis
Disseminated leishmaniasis
Liposomal amphotericin B
dc.subject.en.none.fl_str_mv American tegumentary leishmaniasis
Disseminated leishmaniasis
Liposomal amphotericin B
description Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-08-08T17:20:42Z
dc.date.available.fl_str_mv 2017-08-08T17:20:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACHADO, P. R. L. et al. Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B. Clinical Infectious Diseases, v. 61, p. 945-949, 2015.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/20542
dc.identifier.issn.none.fl_str_mv 1058-4838
dc.identifier.doi.none.fl_str_mv 10.1093/cid/civ416
identifier_str_mv MACHADO, P. R. L. et al. Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B. Clinical Infectious Diseases, v. 61, p. 945-949, 2015.
1058-4838
10.1093/cid/civ416
url https://arca.fiocruz.br/handle/icict/20542
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxfor University Press
publisher.none.fl_str_mv Oxfor University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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