Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet- Induced Type 2 Diabetic Mice
| Main Author: | |
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| Publication Date: | 2022 |
| Other Authors: | , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.2147/DMSO.S365496 |
| Download full: | https://arca.fiocruz.br/handle/icict/57091 |
Summary: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. |
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Rodrigues, Karine LinoSilva, Vivian Vieira Dias daPereira, Evelyn Nunes Goulart da SilvaSilvares, Raquel RangelAraujo, Beatriz Peres deFlores, Edgar Eduardo IlaquitaRamos, Isalira PerobaBorges, Juliana PereiraSantos, Caroline FernandesDaliry, Anissa2023-02-19T13:50:17Z2023-02-19T13:50:17Z2022RODRIGUES, Karine Lino et al. Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet-Induced Type 2 Diabetic Mice. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, v. 15, p. 2991-3005, Sept. 2022.1178-7007https://arca.fiocruz.br/handle/icict/5709110.2147/DMSO.S365496engTaylor & FrancisMicrocirculaçãoTreinamento físicoHiperglicemiaIDADE-FIVAMicrocirculationPhysical trainingAGE-RAGEHyperglycemiaAerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet- Induced Type 2 Diabetic Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro Nacional de Biologia Estrutural e Bioimagem. Rio de Janeiro, RJ, Brasil.Universidade do Rio de Janeiro. Laboratório de Atividade Física e Promoção da Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Departamento de Ciências Básicas. Nova Friburgo, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Purpose: Type 2 diabetic (T2D) patients have liver and adipose tissue microcirculation disturbances associated with metabolic dysfunction and disease progression. However, the potential role of aerobic training on hepatic and white adipose tissue (WAT) microcirculation and the underlying mechanisms have not been elucidated to date. Therefore, we investigated the role of aerobic training on liver and WAT microcirculation and AGE-RAGE modulation in T2D mice. Methods: The control group (CTL) was fed standard chow, and T2D was induced by feeding male C57BL/6 a high-fat, highcarbohydrate diet for 24 weeks. In the following 12 weeks, mice underwent aerobic training (CTL EX and T2D EX groups), or were kept sedentary (CTL and T2D groups). We assessed metabolic parameters, biochemical markers, oxidative damage, the AGE-RAGE axis, hepatic steatosis, hepatic stellate cells activation (HSC) and liver and WAT microcirculation. Results: Hepatic microcirculation was improved in T2D EX mice which were associated with improvements in body, liver and fat mass, blood pressure, hepatic steatosis and fibrosis, and decreased HSC and AGE-RAGE activation. In contrast, improvement in WAT microcirculation, that is, decreased leukocyte recruitment and increased perfusion, was associated with increased catalase antioxidant activity. Conclusion: Physical training improves hepatic and adipose tissue microcirculatory dysfunction associated with T2D, likely due to downregulation of AGE-RAGE axis, decreased HSC activation and increased antioxidant activity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/c6b8248c-6941-415b-95ea-9b72cc4c58fe/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALKarineRodrigues_AlissaDalary_etal_IOC_2022.pdfKarineRodrigues_AlissaDalary_etal_IOC_2022.pdfapplication/pdf7901154https://arca.fiocruz.br/bitstreams/10461529-990f-41cc-8ed1-7b1bb27e867d/downloadf878fa6c229e37204346bf505f448906MD52trueAnonymousREADTEXTKarineRodrigues_AlissaDalary_etal_IOC_2022.pdf.txtKarineRodrigues_AlissaDalary_etal_IOC_2022.pdf.txtExtracted texttext/plain78536https://arca.fiocruz.br/bitstreams/61106d8f-7246-4cff-a45d-2b86211d3a70/download5298495ae6cb89fc96b4c90cad8da78eMD57falseAnonymousREADTHUMBNAILKarineRodrigues_AlissaDalary_etal_IOC_2022.pdf.jpgKarineRodrigues_AlissaDalary_etal_IOC_2022.pdf.jpgGenerated Thumbnailimage/jpeg4986https://arca.fiocruz.br/bitstreams/0a9a7db9-a3f7-4c52-ab31-1934fff35591/downloadd97403422eb71c18946ec206c5886836MD58falseAnonymousREADicict/570912025-07-29 18:22:07.87open.accessoai:arca.fiocruz.br:icict/57091https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-29T21:22:07Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.none.fl_str_mv |
Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet- Induced Type 2 Diabetic Mice |
| title |
Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet- Induced Type 2 Diabetic Mice |
| spellingShingle |
Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet- Induced Type 2 Diabetic Mice Rodrigues, Karine Lino Microcirculação Treinamento físico Hiperglicemia IDADE-FIVA Microcirculation Physical training AGE-RAGE Hyperglycemia |
| title_short |
Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet- Induced Type 2 Diabetic Mice |
| title_full |
Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet- Induced Type 2 Diabetic Mice |
| title_fullStr |
Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet- Induced Type 2 Diabetic Mice |
| title_full_unstemmed |
Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet- Induced Type 2 Diabetic Mice |
| title_sort |
Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet- Induced Type 2 Diabetic Mice |
| author |
Rodrigues, Karine Lino |
| author_facet |
Rodrigues, Karine Lino Silva, Vivian Vieira Dias da Pereira, Evelyn Nunes Goulart da Silva Silvares, Raquel Rangel Araujo, Beatriz Peres de Flores, Edgar Eduardo Ilaquita Ramos, Isalira Peroba Borges, Juliana Pereira Santos, Caroline Fernandes Daliry, Anissa |
| author_role |
author |
| author2 |
Silva, Vivian Vieira Dias da Pereira, Evelyn Nunes Goulart da Silva Silvares, Raquel Rangel Araujo, Beatriz Peres de Flores, Edgar Eduardo Ilaquita Ramos, Isalira Peroba Borges, Juliana Pereira Santos, Caroline Fernandes Daliry, Anissa |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rodrigues, Karine Lino Silva, Vivian Vieira Dias da Pereira, Evelyn Nunes Goulart da Silva Silvares, Raquel Rangel Araujo, Beatriz Peres de Flores, Edgar Eduardo Ilaquita Ramos, Isalira Peroba Borges, Juliana Pereira Santos, Caroline Fernandes Daliry, Anissa |
| dc.subject.other.none.fl_str_mv |
Microcirculação Treinamento físico Hiperglicemia IDADE-FIVA |
| topic |
Microcirculação Treinamento físico Hiperglicemia IDADE-FIVA Microcirculation Physical training AGE-RAGE Hyperglycemia |
| dc.subject.en.none.fl_str_mv |
Microcirculation Physical training AGE-RAGE Hyperglycemia |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2022 |
| dc.date.issued.fl_str_mv |
2022 |
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2023-02-19T13:50:17Z |
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2023-02-19T13:50:17Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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RODRIGUES, Karine Lino et al. Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet-Induced Type 2 Diabetic Mice. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, v. 15, p. 2991-3005, Sept. 2022. |
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https://arca.fiocruz.br/handle/icict/57091 |
| dc.identifier.issn.none.fl_str_mv |
1178-7007 |
| dc.identifier.doi.none.fl_str_mv |
10.2147/DMSO.S365496 |
| identifier_str_mv |
RODRIGUES, Karine Lino et al. Aerobic Exercise Training Improves Microvascular Function and Oxidative Stress Parameters in Diet-Induced Type 2 Diabetic Mice. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, v. 15, p. 2991-3005, Sept. 2022. 1178-7007 10.2147/DMSO.S365496 |
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https://arca.fiocruz.br/handle/icict/57091 |
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eng |
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eng |
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openAccess |
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Taylor & Francis |
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Taylor & Francis |
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