Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Bibliographic Details
Main Author: Lotufo, Paulo A.
Publication Date: 2015
Other Authors: Pereira, Alexandre C., Vasconcellos, Paulo S., Santos, Itamar S., Mill, José Geraldo
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1111/jch.12433
Download full: https://arca.fiocruz.br/handle/icict/10616
Summary: Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil.
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spelling Lotufo, Paulo A.Pereira, Alexandre C.Vasconcellos, Paulo S.Santos, Itamar S.Mill, José Geraldo2015-06-01T19:34:24Z2015-06-01T19:34:24Z2015LOTUFO, Paulo A. et al. Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The Journal of Clinical Hypertension, v.17, n.1, p. 73-80, Jan. 2015.1751-7176https://arca.fiocruz.br/handle/icict/1061610.1111/jch.12433engWiley Online LibraryResistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto do Coração. São Paulo, SP, Brasil.Fundacao Oswaldo Cruz, Rio de Janeiro, Brasil.Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil.Universidade do Espírito Santo. Centro Biomédico. Vitória, ES, Brasil.Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil.The frequency of resistant hypertension-defined as blood pressure (BP) ≥140/90 mm Hg with proven use of three antihypertensive medications, or as the use of four antihypertensive drug classes regardless of BP-is unknown in low-middle-income countries. Using data from the Brazilian Longitudinal Study of Adult Health, a cohort of 15,105 civil servants aged 35 to 74 years, the authors identified 4116 patients taking treatment for hypertension, 11% of who had resistant hypertension. These participants were more likely to be older, black, less educated, poorer, and obese. The adjusted prevalence ratios (95% confidence intervals) were diabetes, 1.44 (1.20-1.72); glomerular filtration rate (<60 mL/min/1.72 m(2) ), 1.95 (1.60-2.38); albumin-to-creatinine ratio (>300 mg/g), 2.43 (1.70-3.50); carotid-femoral pulse-wave velocity, 1.07 m/s (1.03-1.11 m/s); common carotid intima-media thickness, 2.57 mm (1.64-4.00 mm); left ventricular hypertrophy, 2.08 (1.21-3.57); and atrial fibrillation, 3.55 (2.02-6.25). Thus, the prevalence of resistant hypertension in Brazil is high and associated with subclinical markers of end-organ cardiovascular damage.HypertensionBrazilian Longitudinal Study of Adult HealthAtherosclerosisAteroscleroseHipertensãoSaúde do Adultoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://arca.fiocruz.br/bitstreams/ee5bab20-3651-4e54-8cf2-4653c9999714/download7d48279ffeed55da8dfe2f8e81f3b81fMD51falseAnonymousREADORIGINALpaulo_vasconcellosetal_IOC_2015.pdfapplication/pdf196917https://arca.fiocruz.br/bitstreams/eb707b95-0221-4060-b9d2-55ec4a55beda/download17273644ec8090e5ffb808bf9c023679MD52trueAnonymousREADTEXTpaulo_vasconcellosetal_IOC_2015.pdf.txtpaulo_vasconcellosetal_IOC_2015.pdf.txtExtracted texttext/plain38473https://arca.fiocruz.br/bitstreams/33e669ff-4d04-4a84-aa1d-bc47b50049c5/download93d6f3c66002d955fab8f91b76f91410MD55falseAnonymousREADTHUMBNAILpaulo_vasconcellosetal_IOC_2015.pdf.jpgpaulo_vasconcellosetal_IOC_2015.pdf.jpgGenerated Thumbnailimage/jpeg6566https://arca.fiocruz.br/bitstreams/ba9ed72c-ad2e-40a8-a8a1-b741816b314e/downloaddc8c2f7de242f661dafb5767bb503c58MD56falseAnonymousREADicict/106162025-07-29 23:37:31.111open.accessoai:arca.fiocruz.br:icict/10616https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-07-30T02:37:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
dc.title.none.fl_str_mv Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
title Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
spellingShingle Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
Lotufo, Paulo A.
Hypertension
Brazilian Longitudinal Study of Adult Health
Atherosclerosis
Aterosclerose
Hipertensão
Saúde do Adulto
title_short Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
title_full Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
title_fullStr Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
title_full_unstemmed Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
title_sort Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
author Lotufo, Paulo A.
author_facet Lotufo, Paulo A.
Pereira, Alexandre C.
Vasconcellos, Paulo S.
Santos, Itamar S.
Mill, José Geraldo
author_role author
author2 Pereira, Alexandre C.
Vasconcellos, Paulo S.
Santos, Itamar S.
Mill, José Geraldo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lotufo, Paulo A.
Pereira, Alexandre C.
Vasconcellos, Paulo S.
Santos, Itamar S.
Mill, José Geraldo
dc.subject.en.none.fl_str_mv Hypertension
Brazilian Longitudinal Study of Adult Health
Atherosclerosis
topic Hypertension
Brazilian Longitudinal Study of Adult Health
Atherosclerosis
Aterosclerose
Hipertensão
Saúde do Adulto
dc.subject.decs.none.fl_str_mv Aterosclerose
Hipertensão
Saúde do Adulto
description Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-06-01T19:34:24Z
dc.date.available.fl_str_mv 2015-06-01T19:34:24Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LOTUFO, Paulo A. et al. Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The Journal of Clinical Hypertension, v.17, n.1, p. 73-80, Jan. 2015.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/10616
dc.identifier.issn.none.fl_str_mv 1751-7176
dc.identifier.doi.none.fl_str_mv 10.1111/jch.12433
identifier_str_mv LOTUFO, Paulo A. et al. Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The Journal of Clinical Hypertension, v.17, n.1, p. 73-80, Jan. 2015.
1751-7176
10.1111/jch.12433
url https://arca.fiocruz.br/handle/icict/10616
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Wiley Online Library
publisher.none.fl_str_mv Wiley Online Library
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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