THE CANONICAL WNT PATHWAY IN GASTRIC CARCINOMA

• Main Author: OLIVEIRA,Levindo Alves de
• Publication Date: 2019
• Other Authors: OSHIMA,Celina Tizuko Fujiyama, SOFFNER,Pedro Augusto, SILVA,Marcelo de Souza, LINS,Rodrigo Rego, MALINVERNI,Andréa Cristina de Moraes, WAISBERG,Jaques
• Format: Article
• Language: eng
• Source: ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
• Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202019000100302
• topic: Gastric carcinoma; Wnt signaling pathways; Immunohistochemistry; Signal transduction.

ABSTRACT Background : It is believed that the Wnt pathway is one of the most important signaling involved in gastric carcinogenesis. Aim : To analyze the protein expression of canonical and non-canonical Wnt pathways in gastric carcinoma. Method : The immunohistochemistry was performed in 72 specimens of gastric carcinomas for evaluating the expression of Wnt-5a, FZD5, GSK3β, axin, CK1, ubiquitin, cyclin D1 and c-myc. Results : There were significant differences for cytoplasm and nucleus ubiquitin for moderately and well differentiated tumors (p=0.03) and for those of the intestinal type of the Lauren classification (p=0.03). The absence of c-myc was related to Lauren’s intestinal tumors (p=0.03). Expression of CK1 in the cytoplasm was related to compromised margin (p=0.03). Expression of cyclin D1 protein was more intense in male patients (p=0.03) There was no relation of the positive or negative expression of the Wnt-5a, FZD5, GSK3 and Axin with any clinicopathological variables. Conclusion: The canonical WNT pathway is involved in gastric carcinoma.