Short-interfering RNAs as antivirals against rabies

Bibliographic Details
Main Author: Brandão,Paulo Eduardo
Publication Date: 2007
Other Authors: Castilho,Juliana Galera, Fahl,Willian, Carnieli Jr.,Pedro, Oliveira,Rafael de Novaes, Macedo,Carla Isabel, Carrieri,Maria Luiza, Kotait,Ivanete
Format: Article
Language: eng
Source: Brazilian Journal of Infectious Diseases
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200011
Summary: This study aimed to test in vitro a RNA-interference based antiviral approach for rabies with short-interfering RNAs (siRNAs) against rabies virus nucleoprotein mRNA. BHK-21 cells were infected with serial dilutions of PV rabies virus strain and transfected with a pool of three siRNAs. Direct immunofluorescence staining showed a 5-time decrease in virus titer when compared to a non-treated plate, showing a promising new approach to the development of antivirals for rabies treatment.
id BSID-1_e517a55ccd8843e8d6bd62d396d2451e
oai_identifier_str oai:scielo:S1413-86702007000200011
network_acronym_str BSID-1
network_name_str Brazilian Journal of Infectious Diseases
repository_id_str
spelling Short-interfering RNAs as antivirals against rabiessiRNArabiesantiviralThis study aimed to test in vitro a RNA-interference based antiviral approach for rabies with short-interfering RNAs (siRNAs) against rabies virus nucleoprotein mRNA. BHK-21 cells were infected with serial dilutions of PV rabies virus strain and transfected with a pool of three siRNAs. Direct immunofluorescence staining showed a 5-time decrease in virus titer when compared to a non-treated plate, showing a promising new approach to the development of antivirals for rabies treatment.Brazilian Society of Infectious Diseases2007-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200011Brazilian Journal of Infectious Diseases v.11 n.2 2007reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702007000200011info:eu-repo/semantics/openAccessBrandão,Paulo EduardoCastilho,Juliana GaleraFahl,WillianCarnieli Jr.,PedroOliveira,Rafael de NovaesMacedo,Carla IsabelCarrieri,Maria LuizaKotait,Ivaneteeng2007-06-27T00:00:00Zoai:scielo:S1413-86702007000200011Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2007-06-27T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Short-interfering RNAs as antivirals against rabies
title Short-interfering RNAs as antivirals against rabies
spellingShingle Short-interfering RNAs as antivirals against rabies
Brandão,Paulo Eduardo
siRNA
rabies
antiviral
title_short Short-interfering RNAs as antivirals against rabies
title_full Short-interfering RNAs as antivirals against rabies
title_fullStr Short-interfering RNAs as antivirals against rabies
title_full_unstemmed Short-interfering RNAs as antivirals against rabies
title_sort Short-interfering RNAs as antivirals against rabies
author Brandão,Paulo Eduardo
author_facet Brandão,Paulo Eduardo
Castilho,Juliana Galera
Fahl,Willian
Carnieli Jr.,Pedro
Oliveira,Rafael de Novaes
Macedo,Carla Isabel
Carrieri,Maria Luiza
Kotait,Ivanete
author_role author
author2 Castilho,Juliana Galera
Fahl,Willian
Carnieli Jr.,Pedro
Oliveira,Rafael de Novaes
Macedo,Carla Isabel
Carrieri,Maria Luiza
Kotait,Ivanete
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Brandão,Paulo Eduardo
Castilho,Juliana Galera
Fahl,Willian
Carnieli Jr.,Pedro
Oliveira,Rafael de Novaes
Macedo,Carla Isabel
Carrieri,Maria Luiza
Kotait,Ivanete
dc.subject.por.fl_str_mv siRNA
rabies
antiviral
topic siRNA
rabies
antiviral
description This study aimed to test in vitro a RNA-interference based antiviral approach for rabies with short-interfering RNAs (siRNAs) against rabies virus nucleoprotein mRNA. BHK-21 cells were infected with serial dilutions of PV rabies virus strain and transfected with a pool of three siRNAs. Direct immunofluorescence staining showed a 5-time decrease in virus titer when compared to a non-treated plate, showing a promising new approach to the development of antivirals for rabies treatment.
publishDate 2007
dc.date.none.fl_str_mv 2007-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-86702007000200011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.11 n.2 2007
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
_version_ 1754209239821189120

Similar Items