Serum cross-linked n-telopeptides of type 1 collagen (NTx) in patients with solid tumors

• Autor(a) principal: Jablonka, Fernando
• Data de Publicação: 2009
• Outros Autores: Schindler, Fernanda, Lajolo, Paula Philbert, Pinczowski, Hélio, Fonseca, Fernando Luiz Affonso, Barbieri, Antônio, Massonetto, Luiz Henrique, Katto, Fábio Tadashi, Giglio, Auro del
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: São Paulo medical journal (Online)
• Texto Completo: https://periodicosapm.emnuvens.com.br/spmj/article/view/1843
• topic: Neoplasias ósseas; Cintilografia; Valor preditivo dos testes; Fosfatase alcalina; Colágeno tipo I; Bone neoplasms; Radionuclide imaging; Predictive value of tests; Alkaline phosphatase; Collagen type I

CONTEXT AND OBJECTIVE: Cross-linked N-telopeptides of type I collagen (NTx) increase in concentration in situations in which bone resorption is increased, such as osteoporosis and bone metastasis (BM). We aimed to evaluate the serum concentrations of NTx in a sample of patients with several types of solid tumors. DESIGN AND SETTING: Cross-sectional analytical study with a control group in a tertiary public hospital. METHODS: We performed the quantitative enzyme-linked immunosorbent assay (ELISA) on serum NTx levels in 19 subjects without a history of cancer and 62 patients with various solid tumors who had been referred for a bone scan. Three experienced analysts read all bone scans. RESULTS: The serum NTx levels in patients with cancer and BM, with cancer but without BM and without cancer were 46.77 ± 2.58, 32.85 ± 2.05 and 22.32 ± 2.90 respectively (P < 0.0001). We did not find any significant correlations of serum NTx with age, gender, history of bone pain, tumor type and bone alkaline phosphatase levels. We found a significant correlation between serum NTx and alkaline phosphatase levels (R2 = 0.08; P = 0.022). CONCLUSIONS: Serum NTx levels are significantly higher in patients with solid tumors and bone metastases than they are in patients without bone metastases and in normal controls.