Endomyocardial biopsy in Chagas' heart disease: pathogenetic contributions

Bibliographic Details
Main Author: Higuchi, Maria de Lourdes
Publication Date: 1995
Format: Article
Language: eng
Source: São Paulo medical journal (Online)
Download full: https://periodicosapm.emnuvens.com.br/spmj/article/view/1652
Summary: Endomyocardial biopsy procedure has been performed in many centers around the world, allowing a better treatment and follow up of the patients with myocardial disease. In Chagas' disease, it has been performed in São Paulo Heart Institute since 1978 and has brought important contributions to the understanding of the disease and consequently of the patient's clinical stage. In the present work we summarize the principal findings regarding the pathogenesis of Chagas' disease obtained mainly from the studies using endomyocardial biopsy specimens. Nowadays we do not have doubts that the inflammatory infiltrate aggressing myocardial fibers has fundamental role in the progression of the myocardial damage in Chagas' disease what culminates in chronic heart failure. The parasite seems to have active participation in the maintenance of such myocardial inflammation.
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spelling Endomyocardial biopsy in Chagas' heart disease: pathogenetic contributionsEndomyocardial biopsyChagas' diseasePathogenesisTrypanosoma cruziImmunopathologyEndomyocardial biopsy procedure has been performed in many centers around the world, allowing a better treatment and follow up of the patients with myocardial disease. In Chagas' disease, it has been performed in São Paulo Heart Institute since 1978 and has brought important contributions to the understanding of the disease and consequently of the patient's clinical stage. In the present work we summarize the principal findings regarding the pathogenesis of Chagas' disease obtained mainly from the studies using endomyocardial biopsy specimens. Nowadays we do not have doubts that the inflammatory infiltrate aggressing myocardial fibers has fundamental role in the progression of the myocardial damage in Chagas' disease what culminates in chronic heart failure. The parasite seems to have active participation in the maintenance of such myocardial inflammation.O procedimento de biópsia endomiocárdica vem sendo realizado em vários centros do mundo possibilitando melhor acompanhamento e tratamento dos pacientes com doenças do miocárdio. Em relação à doença de Chagas, este procedimento vem sendo executado no Instituto do Coração desde 1978 e tem trazido importantes contribuições no conhecimento da doença e conseqüentemente do estado clínico do paciente. No presente trabalho resumimos os principais avanços em relação à patogenia da doença de Chagas, propiciados principalmente pelos estudos com a biópsia endomiocárdica. Hoje não se tem mais dúvidas de que o infiltrado inflamatório com agressão às fibras miocárdicas tem papel fundamental na progressão do comprometimento miocárdico até levar à insuficiência cardíaca congestiva. O parasita parece ter participação ativa na perpetuação desta inflamação miocárdica.São Paulo Medical JournalSão Paulo Medical Journal1995-03-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicosapm.emnuvens.com.br/spmj/article/view/1652São Paulo Medical Journal; Vol. 113 No. 2 (1995); 821-825São Paulo Medical Journal; v. 113 n. 2 (1995); 821-8251806-9460reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APMenghttps://periodicosapm.emnuvens.com.br/spmj/article/view/1652/1547https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessHiguchi, Maria de Lourdes2023-09-12T10:53:33Zoai:ojs.diagnosticoetratamento.emnuvens.com.br:article/1652Revistahttp://www.scielo.br/spmjPUBhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2023-09-12T10:53:33São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Endomyocardial biopsy in Chagas' heart disease: pathogenetic contributions
title Endomyocardial biopsy in Chagas' heart disease: pathogenetic contributions
spellingShingle Endomyocardial biopsy in Chagas' heart disease: pathogenetic contributions
Higuchi, Maria de Lourdes
Endomyocardial biopsy
Chagas' disease
Pathogenesis
Trypanosoma cruzi
Immunopathology
title_short Endomyocardial biopsy in Chagas' heart disease: pathogenetic contributions
title_full Endomyocardial biopsy in Chagas' heart disease: pathogenetic contributions
title_fullStr Endomyocardial biopsy in Chagas' heart disease: pathogenetic contributions
title_full_unstemmed Endomyocardial biopsy in Chagas' heart disease: pathogenetic contributions
title_sort Endomyocardial biopsy in Chagas' heart disease: pathogenetic contributions
author Higuchi, Maria de Lourdes
author_facet Higuchi, Maria de Lourdes
author_role author
dc.contributor.author.fl_str_mv Higuchi, Maria de Lourdes
dc.subject.por.fl_str_mv Endomyocardial biopsy
Chagas' disease
Pathogenesis
Trypanosoma cruzi
Immunopathology
topic Endomyocardial biopsy
Chagas' disease
Pathogenesis
Trypanosoma cruzi
Immunopathology
description Endomyocardial biopsy procedure has been performed in many centers around the world, allowing a better treatment and follow up of the patients with myocardial disease. In Chagas' disease, it has been performed in São Paulo Heart Institute since 1978 and has brought important contributions to the understanding of the disease and consequently of the patient's clinical stage. In the present work we summarize the principal findings regarding the pathogenesis of Chagas' disease obtained mainly from the studies using endomyocardial biopsy specimens. Nowadays we do not have doubts that the inflammatory infiltrate aggressing myocardial fibers has fundamental role in the progression of the myocardial damage in Chagas' disease what culminates in chronic heart failure. The parasite seems to have active participation in the maintenance of such myocardial inflammation.
publishDate 1995
dc.date.none.fl_str_mv 1995-03-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicosapm.emnuvens.com.br/spmj/article/view/1652
url https://periodicosapm.emnuvens.com.br/spmj/article/view/1652
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicosapm.emnuvens.com.br/spmj/article/view/1652/1547
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv São Paulo Medical Journal
São Paulo Medical Journal
publisher.none.fl_str_mv São Paulo Medical Journal
São Paulo Medical Journal
dc.source.none.fl_str_mv São Paulo Medical Journal; Vol. 113 No. 2 (1995); 821-825
São Paulo Medical Journal; v. 113 n. 2 (1995); 821-825
1806-9460
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
_version_ 1825135066505805824

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