Proton magnetic resonance spectroscopy: clinical applications in patients with brain lesions

Bibliographic Details
Main Author: Ramin, Sérgio Luiz
Publication Date: 2003
Other Authors: Tognola, Waldir Antônio, Spotti, Antonio Ronaldo
Format: Article
Language: eng
Source: São Paulo medical journal (Online)
Download full: https://periodicosapm.emnuvens.com.br/spmj/article/view/2655
Summary: CONTEXT: Proton spectroscopy has been recognized as a safe and noninvasive diagnostic method that, coupled with magnetic resonance imaging techniques, allows for the correlation of anatomical and physiological changes in the metabolic and biochemical processes occurring within previouslydetermined volumes in the brain. There are two methods of proton magnetic resonance spectroscopy: single voxel and chemical shift imaging OBJECTIVE: The present work focused on the clinical applications of proton magnetic resonance spectroscopy in patients with brain lesions. CONCLUSIONS: In vivo proton spectroscopy allows the detection of certain metabolites in brain tissue, such as N-acetyl aspartate, creatine, choline, myoinositol, amino acids and lipids, among others. N-acetyl aspartate is a neuronal marker and, as such, its concentration will decrease in the presence of aggression to the brain. Choline increase is the main indicator of neoplastic diseases. Myoinositol is raised in patients with Alzheimer’s disease. Amino acids are encountered in brain abscesses. The presence of lipids is related to necrotic processes.
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spelling Proton magnetic resonance spectroscopy: clinical applications in patients with brain lesionsEspectroscopia de prótons por ressonância magnética: aplicações clínicas em pacientes com lesões encefálicasEspectroscopia de prótonsRessonância magnéticaEncéfaloProtonSpectroscopyMagnetic resonanceBrainCONTEXT: Proton spectroscopy has been recognized as a safe and noninvasive diagnostic method that, coupled with magnetic resonance imaging techniques, allows for the correlation of anatomical and physiological changes in the metabolic and biochemical processes occurring within previouslydetermined volumes in the brain. There are two methods of proton magnetic resonance spectroscopy: single voxel and chemical shift imaging OBJECTIVE: The present work focused on the clinical applications of proton magnetic resonance spectroscopy in patients with brain lesions. CONCLUSIONS: In vivo proton spectroscopy allows the detection of certain metabolites in brain tissue, such as N-acetyl aspartate, creatine, choline, myoinositol, amino acids and lipids, among others. N-acetyl aspartate is a neuronal marker and, as such, its concentration will decrease in the presence of aggression to the brain. Choline increase is the main indicator of neoplastic diseases. Myoinositol is raised in patients with Alzheimer’s disease. Amino acids are encountered in brain abscesses. The presence of lipids is related to necrotic processes.CONTEXTO: A espectroscopia de prótons é reconhecidamente um método não invasivo que, quando associada à imagem por ressonância magnética, possibilita a correlação de alterações metabólicas e bioquímicas com mudanças fisiológicas e anatômicas dentro de um volume previamente determinado no encéfalo. Existem dois métodos de espectroscopia de prótons por ressonância magnética: volume único de interesse (single voxel) e imagem espectroscópica (chemical shift imaging). OBJETIVO: Este trabalho discute as aplicações clínicas da espectroscopia de prótons por ressonância magnética em pacientes com lesões encefálicas. CONCLUSÕES: A espectroscopia de próton por ressonância magnética in vivo permite detectar alguns metabólitos existentes no tecido encefálico, como N-acetil aspartato, creatina, colina, mio-inositol, aminoácidos, lipídios, entre outros. O N-acetil aspartato é um marcador neuronal cuja concentração diminui quando há lesão encefálica. O aumento na concentração de colina é o principal indicador de doenças neoplásicas. A quantidade de mio-inositol apresenta-se aumentada em casos de doença de Alzheimer. Aminoácidos estão presentes em abscessos encefálicos. A presença de lipídios está relacionada à necrose tecidual.São Paulo Medical JournalSão Paulo Medical Journal2003-11-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicosapm.emnuvens.com.br/spmj/article/view/2655São Paulo Medical Journal; Vol. 121 No. 6 (2003); 254-259São Paulo Medical Journal; v. 121 n. 6 (2003); 254-2591806-9460reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APMenghttps://periodicosapm.emnuvens.com.br/spmj/article/view/2655/2542https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRamin, Sérgio LuizTognola, Waldir AntônioSpotti, Antonio Ronaldo2023-10-09T14:15:45Zoai:ojs.diagnosticoetratamento.emnuvens.com.br:article/2655Revistahttp://www.scielo.br/spmjPUBhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2023-10-09T14:15:45São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Proton magnetic resonance spectroscopy: clinical applications in patients with brain lesions
Espectroscopia de prótons por ressonância magnética: aplicações clínicas em pacientes com lesões encefálicas
title Proton magnetic resonance spectroscopy: clinical applications in patients with brain lesions
spellingShingle Proton magnetic resonance spectroscopy: clinical applications in patients with brain lesions
Ramin, Sérgio Luiz
Espectroscopia de prótons
Ressonância magnética
Encéfalo
Proton
Spectroscopy
Magnetic resonance
Brain
title_short Proton magnetic resonance spectroscopy: clinical applications in patients with brain lesions
title_full Proton magnetic resonance spectroscopy: clinical applications in patients with brain lesions
title_fullStr Proton magnetic resonance spectroscopy: clinical applications in patients with brain lesions
title_full_unstemmed Proton magnetic resonance spectroscopy: clinical applications in patients with brain lesions
title_sort Proton magnetic resonance spectroscopy: clinical applications in patients with brain lesions
author Ramin, Sérgio Luiz
author_facet Ramin, Sérgio Luiz
Tognola, Waldir Antônio
Spotti, Antonio Ronaldo
author_role author
author2 Tognola, Waldir Antônio
Spotti, Antonio Ronaldo
author2_role author
author
dc.contributor.author.fl_str_mv Ramin, Sérgio Luiz
Tognola, Waldir Antônio
Spotti, Antonio Ronaldo
dc.subject.por.fl_str_mv Espectroscopia de prótons
Ressonância magnética
Encéfalo
Proton
Spectroscopy
Magnetic resonance
Brain
topic Espectroscopia de prótons
Ressonância magnética
Encéfalo
Proton
Spectroscopy
Magnetic resonance
Brain
description CONTEXT: Proton spectroscopy has been recognized as a safe and noninvasive diagnostic method that, coupled with magnetic resonance imaging techniques, allows for the correlation of anatomical and physiological changes in the metabolic and biochemical processes occurring within previouslydetermined volumes in the brain. There are two methods of proton magnetic resonance spectroscopy: single voxel and chemical shift imaging OBJECTIVE: The present work focused on the clinical applications of proton magnetic resonance spectroscopy in patients with brain lesions. CONCLUSIONS: In vivo proton spectroscopy allows the detection of certain metabolites in brain tissue, such as N-acetyl aspartate, creatine, choline, myoinositol, amino acids and lipids, among others. N-acetyl aspartate is a neuronal marker and, as such, its concentration will decrease in the presence of aggression to the brain. Choline increase is the main indicator of neoplastic diseases. Myoinositol is raised in patients with Alzheimer’s disease. Amino acids are encountered in brain abscesses. The presence of lipids is related to necrotic processes.
publishDate 2003
dc.date.none.fl_str_mv 2003-11-11
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicosapm.emnuvens.com.br/spmj/article/view/2655
url https://periodicosapm.emnuvens.com.br/spmj/article/view/2655
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicosapm.emnuvens.com.br/spmj/article/view/2655/2542
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv São Paulo Medical Journal
São Paulo Medical Journal
publisher.none.fl_str_mv São Paulo Medical Journal
São Paulo Medical Journal
dc.source.none.fl_str_mv São Paulo Medical Journal; Vol. 121 No. 6 (2003); 254-259
São Paulo Medical Journal; v. 121 n. 6 (2003); 254-259
1806-9460
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
_version_ 1825135077753880576

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