α-Interferon therapy for HBV-related glomerulonephritis

Bibliographic Details
Main Author: Lopes Neto, Edmundo Pessoa de Almeida
Publication Date: 1998
Other Authors: Lopes, Lucila Valente, Kirsztajn, Gianna Mastroianni, Cruz, Cibele Nascimento, Ferraz, Maria Lucia Gomes, Silva, Antonio Eduardo Benedito
Format: Article
Language: eng
Source: São Paulo medical journal (Online)
Download full: https://periodicosapm.emnuvens.com.br/spmj/article/view/2370
Summary: We report a case of a patient with hepatitis B virus (HBV)-related membranous glomerulonephritis (MGN) who showed improvement after interferon-α therapy. A 35-year-old man with nephrotic syndrome and HBV antigens received a 24-week course of IFN-α At the end of therapy there was an elevation in the level of plasma aminotransferase and an increase in proteinuria, which were followed by antigen/antibody seroconversion. This "flare-up" before seroconversion suggests an increase in disease activity in the liver and kidney, demonstrating in vivo HBV involvement in MGN.
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spelling α-Interferon therapy for HBV-related glomerulonephritis Hepatitis B virusMembranous glomerulonephritisInterferonWe report a case of a patient with hepatitis B virus (HBV)-related membranous glomerulonephritis (MGN) who showed improvement after interferon-α therapy. A 35-year-old man with nephrotic syndrome and HBV antigens received a 24-week course of IFN-α At the end of therapy there was an elevation in the level of plasma aminotransferase and an increase in proteinuria, which were followed by antigen/antibody seroconversion. This "flare-up" before seroconversion suggests an increase in disease activity in the liver and kidney, demonstrating in vivo HBV involvement in MGN.Relata-se o caso de um paciente com glomerulopatia membranosa (GNM) associada a infecção pelo vírus da hepatite B (HBV), que apresentou melhora após tratamento com interferon-α. Trata-se de indivíduo de 35 anos, com síndrome nefrótica e hepatite B, tratado com interferon-α por 24 semanas. Ao final do tratamento, observou-se elevação nos níveis de alanina aminotransferase e de proteinúria, com subseqüente soroconversão dos marcadores virais (antígenos para anticorpos). A exacerbação que predeceu a soroconversão deve refletir aumento na atividade da doença tanto a nível renal como hepático, demonstrando in vivo o envolvimento do HBV na GNM.São Paulo Medical JournalSão Paulo Medical Journal1998-09-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicosapm.emnuvens.com.br/spmj/article/view/2370São Paulo Medical Journal; Vol. 116 No. 5 (1998); 1823-1825São Paulo Medical Journal; v. 116 n. 5 (1998); 1823-18251806-9460reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APMenghttps://periodicosapm.emnuvens.com.br/spmj/article/view/2370/2259https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLopes Neto, Edmundo Pessoa de AlmeidaLopes, Lucila ValenteKirsztajn, Gianna MastroianniCruz, Cibele NascimentoFerraz, Maria Lucia GomesSilva, Antonio Eduardo Benedito2023-10-02T14:17:30Zoai:ojs.diagnosticoetratamento.emnuvens.com.br:article/2370Revistahttp://www.scielo.br/spmjPUBhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2023-10-02T14:17:30São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv α-Interferon therapy for HBV-related glomerulonephritis
title α-Interferon therapy for HBV-related glomerulonephritis
spellingShingle α-Interferon therapy for HBV-related glomerulonephritis
Lopes Neto, Edmundo Pessoa de Almeida
Hepatitis B virus
Membranous glomerulonephritis
Interferon
title_short α-Interferon therapy for HBV-related glomerulonephritis
title_full α-Interferon therapy for HBV-related glomerulonephritis
title_fullStr α-Interferon therapy for HBV-related glomerulonephritis
title_full_unstemmed α-Interferon therapy for HBV-related glomerulonephritis
title_sort α-Interferon therapy for HBV-related glomerulonephritis
author Lopes Neto, Edmundo Pessoa de Almeida
author_facet Lopes Neto, Edmundo Pessoa de Almeida
Lopes, Lucila Valente
Kirsztajn, Gianna Mastroianni
Cruz, Cibele Nascimento
Ferraz, Maria Lucia Gomes
Silva, Antonio Eduardo Benedito
author_role author
author2 Lopes, Lucila Valente
Kirsztajn, Gianna Mastroianni
Cruz, Cibele Nascimento
Ferraz, Maria Lucia Gomes
Silva, Antonio Eduardo Benedito
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes Neto, Edmundo Pessoa de Almeida
Lopes, Lucila Valente
Kirsztajn, Gianna Mastroianni
Cruz, Cibele Nascimento
Ferraz, Maria Lucia Gomes
Silva, Antonio Eduardo Benedito
dc.subject.por.fl_str_mv Hepatitis B virus
Membranous glomerulonephritis
Interferon
topic Hepatitis B virus
Membranous glomerulonephritis
Interferon
description We report a case of a patient with hepatitis B virus (HBV)-related membranous glomerulonephritis (MGN) who showed improvement after interferon-α therapy. A 35-year-old man with nephrotic syndrome and HBV antigens received a 24-week course of IFN-α At the end of therapy there was an elevation in the level of plasma aminotransferase and an increase in proteinuria, which were followed by antigen/antibody seroconversion. This "flare-up" before seroconversion suggests an increase in disease activity in the liver and kidney, demonstrating in vivo HBV involvement in MGN.
publishDate 1998
dc.date.none.fl_str_mv 1998-09-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicosapm.emnuvens.com.br/spmj/article/view/2370
url https://periodicosapm.emnuvens.com.br/spmj/article/view/2370
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicosapm.emnuvens.com.br/spmj/article/view/2370/2259
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv São Paulo Medical Journal
São Paulo Medical Journal
publisher.none.fl_str_mv São Paulo Medical Journal
São Paulo Medical Journal
dc.source.none.fl_str_mv São Paulo Medical Journal; Vol. 116 No. 5 (1998); 1823-1825
São Paulo Medical Journal; v. 116 n. 5 (1998); 1823-1825
1806-9460
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
_version_ 1825135074672115712

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