SARS-CoV-2 and arbovirus infection: a rapid systematic review

• Main Author: Milby, Keilla Martins
• Publication Date: 2020
• Other Authors: Atallah, Alvaro Nagib, Rocha-Filho, César Ramos, Pinto, Ana Carolina Pereira Nunes, Rocha, Aline Pereira da, Reis, Felipe Sebastião de Assis, Carvas Junior, Nelson, Civile, Vinicius Tassoni, Santos, Rodolfo Rodrigo Pereira, Ferla, Laura Jantsch, Trevisani, Giulia Fernandes Moça, Ramalho, Gabriel Sodré, Puga, Maria Eduarda dos Santos, Trevisani, Virgínia Fernandes Moça
• Format: Article
• Language: eng
• Source: São Paulo medical journal (Online)
• Download full: https://periodicosapm.emnuvens.com.br/spmj/article/view/566
• topic: Severe acute respiratory syndrome coronavirus 2 [supplementary concept]; Arbovirus infections; Coinfection; Syndemic; Prognosis

BACKGROUND: The numbers of cases of arboviral diseases have increased in tropical and subtropical regions while the coronavirus disease (COVID-19) pandemic overwhelms healthcare systems worldwide. The clinical manifestations of arboviral diseases, especially dengue fever, can be very similar to COVID-19, and misdiagnoses are still a reality. In the meantime, outcomes for patients and healthcare systems in situations of possible syndemic have not yet been clarified. OBJECTIVE: We set out to conduct a systematic review to understand and summarize the evidence relating to clinical manifestations, disease severity and prognoses among patients coinfected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and arboviruses. METHODS: We conducted a rapid systematic review with meta-analysis, on prospective and retrospective cohorts, case-control studies and case series of patients with confirmed diagnoses of SARS-CoV-2 and arboviral infection. We followed the Cochrane Handbook recommendations. We searched EMBASE, MEDLINE, Cochrane Library, LILACS, Scopus and Web of Science to identify published, ongoing and unpublished studies. We planned to extract data and assess the risk of bias and the certainty of evidence of the studies included, using the Quality in Prognosis Studies tool and the Grading of Recommendations Assessment. RESULTS: We were able to retrieve 2,407 citations using the search strategy, but none of the studies fulfilled the inclusion criteria. CONCLUSION: The clinical presentations, disease severity and prognoses of patients coinfected with SARS-CoV-2 and arboviruses remain unclear. Further prospective studies are necessary in order to provide useful information for clinical decision-making processes. PROTOCOL REGISTRATION NUMBER IN THE PROSPERO DATABASE: CRD42020183460