Covid-19 infection in liver transplanted patients

• Main Author: Hyppolito, Elodie Bomfim
• Publication Date: 2021
• Other Authors: Pereira, Heloisa Vidal Alves, Feitosa Neto, Bartolomeu Alves, Miranda, Leda Fátima Rocha, Coelho, Gustavo Rêgo, Mesquita, Denissa Ferreira Gomes de, Garcia, Paulo Ewerton, Silva Filho, Amaury de Castro e, Pires Neto, Roberto da Justa, Girão, Evelyne Santana, Azevedo, Clébia, Gomes, Cynthia Viana Ferreira, Justa, Beatriz Hyppolito da, Mendes, Karen Soares, Fontenele, Thaís Azevedo Souza, Barroso, Júlia do Carmo, Studart, Isabela Carvalho, Caronne, Lívia, Araújo Filho, Antônio Haroldo, Pereira, Karla Brandão, Rocha, Tarciso Daniel dos Santos da, Garcia, José Huygens Parente
• Format: Article
• Language: por
• Source: Brazilian Journal of Transplantation
• Download full: https://bjt.emnuvens.com.br/revista/article/view/418
• topic: Coronavirus Infections; Liver Transplantation; Severe Acute Respiratory Syndrome Coronavirus; Infecç˜ões por Coronavirus; Infecções; Transplante de Fígado; Coronavírus da Síndrome Respiratória Aguda Grave

SARS-Cov-2 (Covid-19) infection is a new clinical condition that has had a profound impact on the entire health system in the world, causing a significant reduction in the performance of organ transplants. The natural history of Covid-19 in liver transplant recipients is unknown. Purpose: To assess clinical manifestations, liver involvement, access to the healthcare system, and mortality of SARS-COV-2 infection (COVID-19) in liver transplanted patients at HUWC-UFC. Methods: We retrospectively assessed in a cross-sectional, observational study a series of 58 suspected cases of COVID-19 in liver transplanted patients at HUWC- UFC. Of these, 18 cases were confirmed to be SARS-CoV-2-infected. Results: The epidemiological profile of this series was that 13 individuals were male, with average age of 58.8 years (Δ35 to 75 years), mean liver transplantation time of 5 years (Δ0.5 to 11 years). All patients in this case series had some comorbidity, with diabetes, overweight and SAH being the most frequent. Most of these patients were treated in a hospital setting, but not all had access to chest tomography, RT-PCR for SARS-CoV-2 or intensive care when necessary. Of the 18 patients, 5 patients died due to coronavirus complications, the majority due to respiratory failure, resulting in a lethality rate of 27.8%. Conclusion: We conclude that Covid-19 infection had high lethality in liver transplanted patients at HUWC-UFC.