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α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties

Bibliographic Details
Main Author: Quintero,Cirley
Publication Date: 2016
Other Authors: Vera,Ricardo, Perez,Leon Dario
Format: Article
Language: eng
Source: Polímeros (São Carlos. Online)
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282016000400304
Summary: Abstract α-Tocopherol is the most bioavailable and active compound found in vitamin E with potential application in pharmaceutical, alimentary and cosmetic industries. However, its low solubility in aqueous medium and environmental instability limit its dosage. In this paper, we report the preparation of α-tocopherol loaded nanoparticles (TOC-NP) based on amphiphilic thermosensitive triblock copolymers PNIPAM-b-PCL-b-PNIPAM. The nanoparticles exhibited a core – shell structure, were positively charged and presented average diameters below 300 nm. TOC-NP presented controlled release of α-tocopherol at room temperature along 140h, and exhibited antioxidant properties in aqueous medium.
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spelling α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant propertiesα-tocopherolpolycaprolactonethermosensitive nanoparticlestriblock copolymerAbstract α-Tocopherol is the most bioavailable and active compound found in vitamin E with potential application in pharmaceutical, alimentary and cosmetic industries. However, its low solubility in aqueous medium and environmental instability limit its dosage. In this paper, we report the preparation of α-tocopherol loaded nanoparticles (TOC-NP) based on amphiphilic thermosensitive triblock copolymers PNIPAM-b-PCL-b-PNIPAM. The nanoparticles exhibited a core – shell structure, were positively charged and presented average diameters below 300 nm. TOC-NP presented controlled release of α-tocopherol at room temperature along 140h, and exhibited antioxidant properties in aqueous medium.Associação Brasileira de Polímeros2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282016000400304Polímeros v.26 n.4 2016reponame:Polímeros (São Carlos. Online)instname:Associação Brasileira de Polímeros (ABPol)instacron:ABPO10.1590/0104-1428.2324info:eu-repo/semantics/openAccessQuintero,CirleyVera,RicardoPerez,Leon Darioeng2016-12-15T00:00:00Zoai:scielo:S0104-14282016000400304Revistahttp://www.scielo.br/pohttps://old.scielo.br/oai/scielo-oai.php||revista@abpol.org.br1678-51690104-1428opendoar:2016-12-15T00:00Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol)false
dc.title.none.fl_str_mv α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties
title α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties
spellingShingle α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties
Quintero,Cirley
α-tocopherol
polycaprolactone
thermosensitive nanoparticles
triblock copolymer
title_short α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties
title_full α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties
title_fullStr α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties
title_full_unstemmed α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties
title_sort α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties
author Quintero,Cirley
author_facet Quintero,Cirley
Vera,Ricardo
Perez,Leon Dario
author_role author
author2 Vera,Ricardo
Perez,Leon Dario
author2_role author
author
dc.contributor.author.fl_str_mv Quintero,Cirley
Vera,Ricardo
Perez,Leon Dario
dc.subject.por.fl_str_mv α-tocopherol
polycaprolactone
thermosensitive nanoparticles
triblock copolymer
topic α-tocopherol
polycaprolactone
thermosensitive nanoparticles
triblock copolymer
description Abstract α-Tocopherol is the most bioavailable and active compound found in vitamin E with potential application in pharmaceutical, alimentary and cosmetic industries. However, its low solubility in aqueous medium and environmental instability limit its dosage. In this paper, we report the preparation of α-tocopherol loaded nanoparticles (TOC-NP) based on amphiphilic thermosensitive triblock copolymers PNIPAM-b-PCL-b-PNIPAM. The nanoparticles exhibited a core – shell structure, were positively charged and presented average diameters below 300 nm. TOC-NP presented controlled release of α-tocopherol at room temperature along 140h, and exhibited antioxidant properties in aqueous medium.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282016000400304
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282016000400304
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0104-1428.2324
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Polímeros
publisher.none.fl_str_mv Associação Brasileira de Polímeros
dc.source.none.fl_str_mv Polímeros v.26 n.4 2016
reponame:Polímeros (São Carlos. Online)
instname:Associação Brasileira de Polímeros (ABPol)
instacron:ABPO
instname_str Associação Brasileira de Polímeros (ABPol)
instacron_str ABPO
institution ABPO
reponame_str Polímeros (São Carlos. Online)
collection Polímeros (São Carlos. Online)
repository.name.fl_str_mv Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol)
repository.mail.fl_str_mv ||revista@abpol.org.br
_version_ 1754212590036189184

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