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Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans

Bibliographic Details
Main Author: MENEZES,RAQUEL T.
Publication Date: 2022
Other Authors: PEREIRA,THAÍS C., JUNQUEIRA,JULIANA C., OLIVEIRA,LUCIANE D., SCORZONI,LILIANA
Format: Article
Language: eng
Source: Anais da Academia Brasileira de Ciências (Online)
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300902
Summary: Abstract This study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH and FLZ, respectively. The capsule size decreased by 67% ​​and 16% when treated with DH and DH with FLZ, respectively. Therefore, this study showed that DH is active against C. neoformans alone and in combination with FLZ, leading to the reduction of the capsule size of this yeast.
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spelling Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformansCryptococcus neoformanscapsulefluconazoleduloxetine hydrochloridesynergistic combinationAbstract This study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH and FLZ, respectively. The capsule size decreased by 67% ​​and 16% when treated with DH and DH with FLZ, respectively. Therefore, this study showed that DH is active against C. neoformans alone and in combination with FLZ, leading to the reduction of the capsule size of this yeast.Academia Brasileira de Ciências2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300902Anais da Academia Brasileira de Ciências v.94 n.2 2022reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202220211021info:eu-repo/semantics/openAccessMENEZES,RAQUEL T.PEREIRA,THAÍS C.JUNQUEIRA,JULIANA C.OLIVEIRA,LUCIANE D.SCORZONI,LILIANAeng2022-05-04T00:00:00Zoai:scielo:S0001-37652022000300902Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2022-05-04T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
title Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
spellingShingle Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
MENEZES,RAQUEL T.
Cryptococcus neoformans
capsule
fluconazole
duloxetine hydrochloride
synergistic combination
title_short Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
title_full Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
title_fullStr Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
title_full_unstemmed Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
title_sort Synergistic combination of duloxetine hydrochloride and fluconazole reduces the cell growth and capsule size of Cryptococcus neoformans
author MENEZES,RAQUEL T.
author_facet MENEZES,RAQUEL T.
PEREIRA,THAÍS C.
JUNQUEIRA,JULIANA C.
OLIVEIRA,LUCIANE D.
SCORZONI,LILIANA
author_role author
author2 PEREIRA,THAÍS C.
JUNQUEIRA,JULIANA C.
OLIVEIRA,LUCIANE D.
SCORZONI,LILIANA
author2_role author
author
author
author
dc.contributor.author.fl_str_mv MENEZES,RAQUEL T.
PEREIRA,THAÍS C.
JUNQUEIRA,JULIANA C.
OLIVEIRA,LUCIANE D.
SCORZONI,LILIANA
dc.subject.por.fl_str_mv Cryptococcus neoformans
capsule
fluconazole
duloxetine hydrochloride
synergistic combination
topic Cryptococcus neoformans
capsule
fluconazole
duloxetine hydrochloride
synergistic combination
description Abstract This study aimed to evaluate the effect of duloxetine hydrochloride (DH) on Cryptococcus neoformans. DH minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 18.5 µg/mL, and the combination with fluconazole (FLZ) reduced the MIC value by 16-and 4-fold for DH and FLZ, respectively. The capsule size decreased by 67% ​​and 16% when treated with DH and DH with FLZ, respectively. Therefore, this study showed that DH is active against C. neoformans alone and in combination with FLZ, leading to the reduction of the capsule size of this yeast.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300902
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300902
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765202220211021
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.94 n.2 2022
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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