Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues

Detalhes bibliográficos
Autor(a) principal: Nabavi,Seyed M.
Data de Publicação: 2012
Outros Autores: Nabavi,Seyed F., Moghaddam,Akbar H., Setzer,William N., Mirzaei,Morteza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400026
Resumo: This study aim to evaluate the protective effect of silymarin on sodium fluoride-induced oxidative stress in rat cardiac tissues. Animals were pretreated with silymarin at 20 and 10 mg/kg prior to sodium fluoride consumption (600 ppm through drinking water). Vitamin C at 10 mg/kg was used as standard antioxidant. There was a significant increase in thiobarbituric acid reactive substances level (59.36 ± 2.19 nmol MDA eq/g tissue) along with a decrease in antioxidant enzymes activity (64.27 ± 1.98 U/g tissue for superoxide dismutase activity and 29.17 ± 1.01 µmol/min/mg protein for catalase activity) and reduced glutathione level (3.8 ± 0.15 µg/mg protein) in the tissues homogenates of the sodium fluoride-intoxicated rats. Silymarin administration to animals before sodium fluoride consumption modified the levels of biochemical parameters.
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spelling Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissuescatalaseglutathionesodium fluoridesuperoxide dismutasesilymarinTBARSThis study aim to evaluate the protective effect of silymarin on sodium fluoride-induced oxidative stress in rat cardiac tissues. Animals were pretreated with silymarin at 20 and 10 mg/kg prior to sodium fluoride consumption (600 ppm through drinking water). Vitamin C at 10 mg/kg was used as standard antioxidant. There was a significant increase in thiobarbituric acid reactive substances level (59.36 ± 2.19 nmol MDA eq/g tissue) along with a decrease in antioxidant enzymes activity (64.27 ± 1.98 U/g tissue for superoxide dismutase activity and 29.17 ± 1.01 µmol/min/mg protein for catalase activity) and reduced glutathione level (3.8 ± 0.15 µg/mg protein) in the tissues homogenates of the sodium fluoride-intoxicated rats. Silymarin administration to animals before sodium fluoride consumption modified the levels of biochemical parameters.Academia Brasileira de Ciências2012-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400026Anais da Academia Brasileira de Ciências v.84 n.4 2012reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652012005000056info:eu-repo/semantics/openAccessNabavi,Seyed M.Nabavi,Seyed F.Moghaddam,Akbar H.Setzer,William N.Mirzaei,Mortezaeng2012-11-29T00:00:00Zoai:scielo:S0001-37652012000400026Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2012-11-29T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
title Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
spellingShingle Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
Nabavi,Seyed M.
catalase
glutathione
sodium fluoride
superoxide dismutase
silymarin
TBARS
title_short Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
title_full Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
title_fullStr Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
title_full_unstemmed Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
title_sort Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
author Nabavi,Seyed M.
author_facet Nabavi,Seyed M.
Nabavi,Seyed F.
Moghaddam,Akbar H.
Setzer,William N.
Mirzaei,Morteza
author_role author
author2 Nabavi,Seyed F.
Moghaddam,Akbar H.
Setzer,William N.
Mirzaei,Morteza
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Nabavi,Seyed M.
Nabavi,Seyed F.
Moghaddam,Akbar H.
Setzer,William N.
Mirzaei,Morteza
dc.subject.por.fl_str_mv catalase
glutathione
sodium fluoride
superoxide dismutase
silymarin
TBARS
topic catalase
glutathione
sodium fluoride
superoxide dismutase
silymarin
TBARS
description This study aim to evaluate the protective effect of silymarin on sodium fluoride-induced oxidative stress in rat cardiac tissues. Animals were pretreated with silymarin at 20 and 10 mg/kg prior to sodium fluoride consumption (600 ppm through drinking water). Vitamin C at 10 mg/kg was used as standard antioxidant. There was a significant increase in thiobarbituric acid reactive substances level (59.36 ± 2.19 nmol MDA eq/g tissue) along with a decrease in antioxidant enzymes activity (64.27 ± 1.98 U/g tissue for superoxide dismutase activity and 29.17 ± 1.01 µmol/min/mg protein for catalase activity) and reduced glutathione level (3.8 ± 0.15 µg/mg protein) in the tissues homogenates of the sodium fluoride-intoxicated rats. Silymarin administration to animals before sodium fluoride consumption modified the levels of biochemical parameters.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400026
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400026
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37652012005000056
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.84 n.4 2012
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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