Photoprotection / photostabilizer potential in a quercetin sunscreens: determination of physical-chemical, safety and efficacy properties

Detalhes bibliográficos
Ano de defesa: 2019
Autor(a) principal: Garcia, Mirela Cardoso
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: eng
Instituição de defesa: Biblioteca Digitais de Teses e Dissertações da USP
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://www.teses.usp.br/teses/disponiveis/9/9139/tde-02102019-120356/
Resumo: Ultraviolet radiation (UV) is related to the development of skin cancer and photoaging, also produces free radicals or reactive oxygen species (ROS) that cause premature aging. Therefore, sunscreens with extended UV protection capacity have been studied associated with antioxidant compounds. Different components can be incorporated with the purpose of improving, the photoprotection efficiency, as well as other cosmetic attributes, creating a multifunctional product. Among the compounds, there are some to be used from natural origin that are excellent, because it reduces the side effects and toxicity. Flavonoids are good examples of natural agents, because have demonstrated photoprotective antioxidant action in food and it is also promising for topical use. The aim of this work is to develop photoprotective formulations with quercetin, evaluating potential photoprotective and antioxidant of each formulation through tests already established and described in the literature, with emphasis on in vitro testing of potential photoprotective, antioxidant and security (het-cam); ex vivo antioxidant potential (tape-stripping). The results show us the photoprotective and antioxidant capacity of quercetin and the ideal concentration for this potential, thereby contributing to the synthesis of new molecules and development of new products, concerning stable, safe and effective exposure to solar UV radiation, preventing new incidences of skin cancer and reduction of photoaging.