Avaliação morfológica e histomorfométrica da reabsorção de blocos de enxerto ósseo autógeno da calota craniana de coelhos que receberam alendronato de sódio

• Ano de defesa: 2011
• Autor(a) principal: Rosa, Teo Mario da
• Orientador(a): Gonçales, Eduardo Sanches
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: IASCJ - Universidade Sagrado Coração
• Programa de Pós-Graduação: Cirurgia Bucomaxilofacial
• Departamento: Ciências da Saúde e Biológicas
• País: BR
• Palavras-chave em Português: ENXERTO; REABSORÇÃO; BIFOSFONATOS
• Palavras-chave em Inglês: BONE GRAFT; RESORPTION; BISPHOSPHONATES
• Área do conhecimento CNPq: ODONTOLOGIA::CIRURGIA BUCO-MAXILO-FACIAL
• Link de acesso: http://localhost:8080/tede/handle/tede/54

Introduction: Bisphosphonates are synthetic drugs and are characterized as potente inhibitors of bone resorption. To ensure the event of osseointegration and provide oral health through chewing the costs of prostheses supported by implants osseintegráveis, sometimes, we employed the technique of reconstruction with autogenous bone graft jaws with intent to enable mechanical and biological success for our prosthetic rehabilitation. We know that during the process of incorporation of bone grafts for varying rates of resorption mediated by osteoclasts. Our goal was to evaluate morphological and histomorphometric levels of resorption of bone allograft blocks in the skull of New Zealand rabbits with and without the administration of the bisphosphonate, alendronate sodium. The methodology used at work was: Administrative 4mg/semanal dose in a test group of 16 New Zealand rabbits divided equally into 4 groups after undergoing surgery to remove a bone block of 8 mm in diameter the contralateral parietal bone and fixed by screws. Evaluation periods were 7, 14, 30 and 60 days. The test group was compared with the control group, with the same 16 rabbits, the surgical procedure and period of analysis, but this group was not given the drug. Morphological description was carried out in all periods and histomorphometry to compare the thickness of the graft during surgery with periods of 30 and 60 days after surgery in both groups also evaluated the newly formed bone-graft interface of the receptor in the early periods of 7 and 14 days in both groups. The statistical tests used for analysis were the Wicoxom and Mann Whitney. The results, according to the methodology mentioned above, we observed no difference in rates of resorption after the final incorporation of the graft between the alendronate group and the control group.