Detalhes bibliográficos
| Ano de defesa: |
2018 |
| Autor(a) principal: |
Santos, Ligiane Souza dos
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| Orientador(a): |
Carvalho, Rodrigo Leal de Paiva
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| Banca de defesa: |
Não Informado pela instituição |
| Tipo de documento: |
Dissertação
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| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade do Sagrado Coração
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| Programa de Pós-Graduação: |
Saúde Funcional
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| Departamento: |
Ciências da Saúde e Biológicas
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| País: |
Brasil
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| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://tede2.usc.br:8080/jspui/handle/tede/404
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Resumo: |
Patients with Diabetes Mellitus (DM) perform as a form of prevention, treatment and even reduction of other risk factors, aerobic physical exercises and resistance. However, traumatic muscular injuries are common during the practice of physical activity, which can cause functional loss, histological and morphological changes in varying degrees. Different types of pharmacological and non-pharmacological therapies are prescribed in the treatment and recovery of musculoskeletal injuries, such as anti-inflammatory drugs and low-power laser therapy. Physiologically, after a lesion, the process of musculoskeletal repair in rats lasts approximately 28 days until its completion, however little is known about the morphological, histological and functional recovery at the end of this process of muscle tissue repair, in the case of diabetes. The objective of this study was to evaluate the recovery of muscle tissue during and at the end of the repair process (14 and 28 days), through morphometric, histological and functional analysis after traumatic muscle injury in diabetic rats, using laser therapy low potency and diclofenac, alone or in combination. To induce the lesion, the animals received a single trauma to the right hind limb. Treatments occurred one hour after the lesion protocol. Laser irradiation was performed at only one point in the trauma region, at the energy dose of 3 J, for 30 s. Diclofenac was applied at the dose of 11.6 mg / g -1 (milligram gram) topically. Morphometric, histological and functional analyzes of the muscle tissue were performed 14 and 28 days after the induction of the lesion. The results obtained show that in the morphometric aspects at 14 days, the Laser group showed a greater muscle fiber area when compared to the Laser + Diclo group and similar to the healthy group (94.42 ± 2.1). At 28 days the results were similar to the group of 14 days. In the 14-day functional analysis, it can be observed that the Laser (-6.8 ± 0.3) and Laser + Diclo (-8.67 ± 0.3) groups showed improved gait pattern when compared to the other groups, and the Laser group obtained a better walking pattern, when compared to the Laser + Diclo group, demonstrated gait pattern similar to the healthy group (-6.67 ± 0.2). At 28 days, the groups obtained a similar pattern of gait in the 14-day groups. In the histological aspects, the group that received only the Laser showed a qualitative improvement, with better organization of the cells of the muscular tissue, less amount of red blood cells and extracellular matrix with less wave profile, when compared to the other groups, not even avoiding the appearance of the signs typical of injury.It was concluded that the Laser was the most effective treatment in the repair of the muscular tissue in the time of 14 and 28 days and obtained positive results in the functional, morphometric and histological regeneration of the muscular tissue. |
