Detalhes bibliográficos
| Ano de defesa: |
2007 |
| Autor(a) principal: |
Piozzi, Rodrigo
 |
| Orientador(a): |
Matsumoto, Mariza Akemi
|
| Banca de defesa: |
Não Informado pela instituição |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
IASCJ - Universidade Sagrado Coração
|
| Programa de Pós-Graduação: |
Cirurgia Bucomaxilofacial
|
| Departamento: |
Ciências da Saúde e Biológicas
|
| País: |
BR
|
| Palavras-chave em Português: |
|
| Palavras-chave em Inglês: |
|
| Área do conhecimento CNPq: |
|
| Link de acesso: |
http://localhost:8080/tede/handle/tede/95
|
Resumo: |
Internal fixture materials are currently used as metallic biomaterials in rehabilitation of human body. Nevertheless, metalsrelease due to corrosion phenomena appear to play a crucial role for human health. Thus, the goal of the present study was to evaluate whether liver, kidney and lung are particularly sensitive organs for DNA damaging and cytotoxicity following implantantion of internal fixture materials composed by titanium alloy in vivo. A total of 18 rats underwent surgical titanium miniplates in their tibias, being randomly distributed into three groups: Group 1) 30 days; Group 2) 90 days and Group 3) 180 days after implantation. A total of six animals served as negative control (animals that not received any implant). After experimental design, the lung, liver and kidney were removed for histopatological, and genotoxic analysis as depicted by H.E. stain and single cell gel (comet) assay, respectively. No significant statistically differences (p>0.05) for DNA damaging were found to all experimental groups when compared to negative control for all organs evaluated. In addition, no remarkable morphological alterations were detected under histopathological analysis. Taken together, such results suggest that titanium miniplates are not able to induce DNA damage in multiple organs nor to cause some abnormalities in lung, liver and kidney. |
