Detalhes bibliográficos
| Ano de defesa: |
2013 |
| Autor(a) principal: |
NEVES, Gesilda Florenço das |
| Orientador(a): |
NOGUEIRA, Romildo de Albuquerque |
| Banca de defesa: |
JIMENEZ, George Chaves,
FERNANDES, Thiago de Salazar e,
RODRIGUES, Cláudio Gabriel,
ALBERTINI, Alessandro Victor Patrício de |
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Federal Rural de Pernambuco
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Biociência Animal
|
| Departamento: |
Departamento de Morfologia e Fisiologia Animal
|
| País: |
Brasil
|
| Palavras-chave em Português: |
|
| Área do conhecimento CNPq: |
|
| Link de acesso: |
http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4552
|
Resumo: |
From the 50s, researchers have raised interest in discovering the structure and function of the cell membranes, the flow of ionic currents along those membranes, its mechanisms of transport and voltage variations. These studies allowed the construction of a model for description of the action potential in membranes of neurons, enabling simulations of nerve impulses. The increasing search for theoretically studying the electrical activity of other cells, proposed creating other modeling, including that can represent the activity of pancreatic β cells. Knowing the growth indicated by the World Health Organization (WHO) on diabetes in the coming years, to seek possible means of therapy for patients who suffer from this metabolic disorder. An interesting fact is that the introduction of numerous processes electrification of cities and the use of electronic devices emitting electric fields, have been shown to alter cellular mechanisms. So if the electric field stimulate or inhibit the synthesis and secretion of insulin by pancreatic β cells, this agent could be used in future as a potential therapy for diabetes. Therefore, this study aimed through mathematical models simulate the electrical potential and ionic currents in the membrane of pancreatic β-cells in the presence of electric fields, in order to investigate possible changes in the electrical behavior of the membrane of these cells. The search for new theoretical and experimental models, such as exposure to an electric field, consists of an innovative idea and could pave the way for alternative therapies for diseases such as type II diabetes mellitus when treatment with drugs is not effective, in addition to understanding whether no deleterious effects from exposure to the electric field. |
