Incorporación de myristyltrimethylammonium bromide en un adhesivo experimental

• Ano de defesa: 2018
• Autor(a) principal: Mogollón, Gustavo Huertas
• Orientador(a): Leitune, Vicente Castelo Branco
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: eng
• Palavras-chave em Português: Polimerização; Cárie dentária; Streptococcus mutans; Adesivos dentinários; Antibacterianos
• Palavras-chave em Inglês: Polymerization; Dental caries; Dentin-bonding agents; Antibacterial agents
• Link de acesso: http://hdl.handle.net/10183/252834

The aim of this study was to evaluate the effect of the addition of myristyl trimethyl ammonium bromide on the physicochemical and biological properties of an experimental adhesive resin. The adhesive resin was formulated with methacrylate monomers and a photoinitiator system. The quaternary ammonium compound myristyltrimethyl ammonium bromide was added at 0.5 (G0.5%); 1 (G1%) and 2% (G2%) in the adhesive resin. A group without the addition of this compound was used as a control (GCtrl). The resins were evaluated for polymerization kinetics, degree of conversion (n=3) and cohesive strength (n=5), contact angle and surface free energy (n=5), cytotoxicity (n=5) and antibacterial activity. against biofilm formation (n=3) and planktonic bacteria (n=3). The polymerization kinetics were similar between all groups and there was no difference regarding ultimate tensile strength too (p>0.05), but there was difference only between G0.5% and G1% for degree of conversion. There was no difference between groups for the water contact angle (p>0.05). G2% had the highest contact angle value with αbromonaphthalene (p<0.05), but there was no difference between groups regarding surface free energy (p>0.05). Cell viability values ranged between 90.43% (±3.35) for GCtrl and 40.79% (±8.44) for G2%, with no statistical difference between GCtrl and G0.5% (p>0.05). All groups with the quaternary compound showed antibacterial activity in the two tests (p<0.05). It was concluded that the addition of 0.5% of myristyltrimethyl ammonium bromide induced antibacterial activity, without a cytotoxic effect and without altering the physicochemical properties of the adhesive resin.