Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer

Detalhes bibliográficos
Ano de defesa: 2012
Autor(a) principal: Borba, Ericksen Mielle
Orientador(a): Chaves, Marcia Lorena Fagundes
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Não Informado pela instituição
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: http://hdl.handle.net/10183/37451
Resumo: Background: It has been suggested that there is an association between brain-derived neurotrophic factor (BDNF) and the neuropathology of Alzheimer’s disease (AD). However, little is known about the role of BDNF in subjects with mild cognitive impairment (MCI). In the present study, we investigated BDNF serum levels in healthy elderly, amnestic MCI, and mild to moderate AD patients in order to identify a possible role for this neurotrophin in preclinical and early stages of AD. Methods: BDNF serum levels were measured by sandwich-ELISA in healthy elderly (n=20), amnestic MCI patients (n=15) and AD patients (n=25), 12 mild and 13 moderate. MMSE scores, level of education and age were analyzed for a possible correlation with BDNF levels. Results: BDNF serum levels were significantly different between MCI patients and healthy subjects (p=0.003); MCI and mild AD patients (p=0.023); and MCI and moderate AD patients (p=0.050). BDNF showed no correlation with MMSE scores, age or level of education. Limitations: The small sample size in the present investigation could be a limitation. However, we carried out a power calculation that showed values higher than 80% for a confidence level of 95%. Conclusion: The fact that BDNF serum levels differentiated amnestic MCI patients from healthy elderly and AD patients suggests a possible role for BDNF as a preclinical biomarker of AD.