Efeito protetor do suco de laranja vermelha e dieta hiperlipídica nos parâmetros fisiológicos e marcadores bioquímicos em ratos submetidos à dieta hiperlipídica

• Ano de defesa: 2014
• Autor(a) principal: Massafera, Gisele [UNESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Suco de laranja; Glicemia; Stress oxidativo
• Link de acesso: http://hdl.handle.net/11449/110798

It has been shown that regular consumption of yellow pulp orange juice improves the lipid profile, blood pressure, insulin sensitivity, and oxidative stress and, reduces the systemic inflammatory state in man and experimental animals. On the other hand, little is known about the effects of the red pulp orange juice (RPOJ), which have different contents of bioactive components, for example, less amount of vitamin C, but higher amounts of carotenoids. The objective of this study was to investigate the effect of RPOJ on the lipid profile, body composition and hepatic protection in rats treated with high-fat diet, which simulates important deleterious effects associated with the development of chronic diseases. Adult rats (n=60) were divided into 6 groups that were treated with standard or high-fat diet associated with three types of drink intake: water, RPOJ or test drink (solution of water plus sugar), the treatment lasted 30 days and measurements of body weight and food intake were made. At the end of the period the animals were euthanized and biochemical parameters were determinated in the blood serum. Organs (kidney, spleen and liver) and abdominal fat were collected for further analysis. The results showed that the groups treated with high-fat diet gained more body mass at the end of the period. All groups that received standard diet, regardless of fluid intake (water, SLV, or drink test), showed higher feed intake. Animals treated with SLV showed lower feed intake and increased water consumption compared to their controls. Both glucose and triglycerides in blood serum was decreased in the groups treated with the fat diet. Serum cholesterol was increased by high-fat diet but was reduced by the intake of RPOJ. Liver enzymes, AST and ALT showed no effects of diet or water intake, but the ALP was reduced in animals receiving RPOJ, regardless of the type of diet. There was accumulation of abdominal fat and liver fat in groups treated with ...