Efeitos da noradrenalina e dobutamina sobre a expansão volêmica com solução fisiológica e coelhos submetidos à hemorragia

• Ano de defesa: 2015
• Autor(a) principal: Ramalho, Gualter Lisboa [UNESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Norepinefrina; Hemorragia; Catecolaminas; Coelho como animal de laboratorio; Anestesiologia; Anesthesiology
• Link de acesso: http://hdl.handle.net/11449/142968; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/05-07-2016/000865024.pdf

Introduction: the infusion of crystalloid solutions is a routine treatment in patients undergoing anesthesia and surgical procedures, especially in hemorrhagic conditions. However, the crystalloids present poor volemic expansion, remaining twenty percent or less of the total infused in the cardiovascular system after twenty minutes of infusion, leading to volume overload. In order to minimize the risk posed by this overload, vasoactive drugs with vasopressor and inotropic properties are commonly administered together with the infusion of volume expanders. Objectives: to verify the effects of dobutamine (DB), noradrenaline (NA) and their combination (NADB) on the expansion and the intravascular volume retention with saline solution in rabbits submitted to hemorrhage. Method: a total of 36 rabbits were randomly divided into six experimental groups: SHAM Group - animals submitted to the surgical procedure without hemorrhage or volume replacement. For the other groups, the animals were submitted to hemorrhage of 25% of volume with replacement with their own blood in the Control Group (CG) or, with saline solution in volume referring to three times the blood drawn from the other groups. In the NA Group, the noradrenaline, at a dose of 1,6 ug/kg/min, was associated with the infusion of saline solution (SS); in the DB Group, the dobutamine, at a dose of 10 ug/kg/min, was associated with the infusion of saline solution(SS); and in the NADB Group, the dobutamine and noradrenaline, at a dose of 1,6 ug/kg/min and at a dose of 10 ug/kg/min, respectively, were associated with the infusion of SS. During the experiment, the intravascular retention of crystalloid solution, diuresis, central venous pressure (CVP), mean arterial pressure (MAP), CPK-MB, NGAL, plasma lactate and dry and wet lung weight were monitored. Results: after the hemorrhage, the animals presented a significant decrease in the mean arterial pressure (MAP) which was maintained up to ...