Efeito protetor da coenzima Q10 sobre os danos oxidativos da L-Tiroxina no músculo sóleo de ratos: Fabiana Barreiro de Freitas Silva. -
| Ano de defesa: | 2014 |
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| Autor(a) principal: | |
| Orientador(a): | |
| Banca de defesa: | |
| Tipo de documento: | Dissertação |
| Tipo de acesso: | Acesso aberto |
| Idioma: | por |
| Instituição de defesa: |
Universidade Estadual Paulista (Unesp)
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| Programa de Pós-Graduação: |
Não Informado pela instituição
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| Departamento: |
Não Informado pela instituição
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| País: |
Não Informado pela instituição
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| Palavras-chave em Português: | |
| Link de acesso: | http://hdl.handle.net/11449/124446 http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/19-06-2015/000836295.pdf |
Resumo: | Skeletal muscles are dynamic tissues that can alter their phenotypic characteristics providing better functional adaptation to different stimulus.The hability to adapt the muscle tissue during growth and exercise is dependent on qualitative and quantitative changes in expression induced by various stimuli. L-thyroxine is a hormone produced by the thyroid gland and has been used as an experimental model for stimulation of oxidative stress in skeletal muscle.CoQ10 is a fat-soluble provitamin endogenously synthesized and naturally found in foods like red meat, fish, grains, broccoli and spinach.Features antioxidant properties and potential in the treatment of degenerative diseases and neuromuscular diseases.The present study evaluated the protective effect of CoQ10 in the soleus muscle against damage caused by L-thyroxine .The rats were divided in to four groups of six animals each: Group 1(G1, Control); Group 2(G2, coenzyme Q10); Group 3 (G3, L-thyroxine) and Group 4 (G4, coenzyme Q10 and L -thyroxine) .After euthanasia, blood was collected and serum was analyzed activity of the enzymes creatine kinase (CK) and aspartate aminotransferase (AST).In the soleus muscle homogenate factors related to oxidative stress were evaluated. CoQ10 protected the soleus muscle and favored the maintenance of the antioxidant enzymes glutathione reductase and glutathione peroxidase, the concentration of reduced and oxidized glutathione, and prevent lipid peroxidation. The results indicate that CoQ10 protects rat soleus muscle from oxidative damage caused by L- thyroxine |