Síntese, caracterização e avaliação da atividade biológica de metalofármacos de sulindaco com íons lantanídeos (III) no estado sólido

• Ano de defesa: 2015
• Autor(a) principal: Guerra, Renan Barrach [UNESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Metais de terras raras; Metalogenia; Rare earth metals
• Link de acesso: http://hdl.handle.net/11449/132603; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/07-01-2016/000855142.pdf

Synthesis and characterization of complexes of the anti-inflammatory drug nonsteroidal sulindac (sulin) with the lanthanide ions (Ln3+) La3+, Ce3+, Pr3+, Nd3+, Gd3+, Tb3+ and Ho3+ in the solid state area described in this work. The characterization of the pharmaceutical and the complexes was performed using simultaneous thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry-photovisual (DSC-photovisual), coupled thermogravimetry-infrared spectroscopy (TG-FTIR) analyses, complexometric titranion with EDTA and elemental analysis, and also use of X-ray diffraction by the powder method and vibrational spectroscopy reflectance in the infrared Fourier transform spectroscopy (FTIR). The thermal analysis results provided information concerning the thermal stability, dehydration and the thermal behavior of the compounds and along with the compleximetric titration and elemental analysis, it was possible to determine the stoichiometry of the complex as [Ln(sulin)3]XH2O. The spectroscopic results suggest that the ligand sulindac coordinates through the carboxylate group to the metals as a bidentatebrinding ligand. Tests for cytotoxicity and anti-inflammatory activity of the synthesized compounds demonstrated tha the complexes in general have very similar behavior in comparison to the drug. However, the results suggest that [Gd(sluin)3] has potential for pharmacological improvement