Relação entre toxicidade urêmica, anemia e perda auditiva neurossensorial em indivíduos com doença renal crônica: um estudo prospectivo

• Ano de defesa: 2014
• Autor(a) principal: Lopez, Priscila Suman [UNESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Rins - Doenças; Insuficiencia renal cronica; Anemia; Uremia; Disturbios da audição; Renal insufficiency, Chronic
• Link de acesso: http://hdl.handle.net/11449/114038

Patients in the chronic kidney disease (CKD) have a higher risk of developing sensorineural hearing loss (SNHL) concerning the general population, independently of age, gender, diabetes and/ or hypertension. Aim: To study the relationship between uremic toxicity, anemia, stage of CKD and SNHL in CKD patients followed for two years. Methods: Prospective clinical study in a tertiary hospital. The blood measures and hearing loss were performed by the audiometry (PTA), evoked otoacoustic emissions (OAE) and auditory brainstem response (ABR) tests in two moments (M1 was the baseline and M2 two years later). Forty-three(43) patients were included and they were selected by using these criteria: they suffered from CKD at any stage, they underwent any type of treatment in the local institution, maximum age of 60, tympanometric curve A in both ears and moments, without congenital hearing loss, genetic syndromes, mental disabilities, excessive noise exposure, no administration aminoglycosides and/or renal transplantation. Results: The most patients were male (58%), of white race (91%), median age 53 years, 40 months of CKD and arterial hypertension (65% in M1 and 67% in M2). In M1, the conservative method was more frequent (63%) with stage 4 and 5 CKD (37 %). In the second evaluation 25% of the patients showed worsening of CKD stage. SNHL affected 28% of patients in M1 and 33% in M2, absence of EOE- T was observed in 34 % of patients in M1 and 45% in M2. ABR changes were observed in 21% of patients in M1 and 26 % in M2. Hearing deterioration was observed in 24% of PTA patients, 11% of EOE-T and 16% of ABR. Among the blood markers, high initial levels of beta2- microglobulin and low initial levels hematocrit and hemoglobin were associated with higher risk of abnormal ABR. The stage of CKD was not associated with sensorineural hearing loss