Correlação das características ultrassonográficas com perfil imunoistoquímico dos tumores mamários malignos

• Ano de defesa: 2014
• Autor(a) principal: Pessoa, Carla Priscila Kamiya Carvalho [UNESP]
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Mamas - Cancer; Diagnóstico imunohistoquímico; Ultrassonografia; Expressão gênica; Tumores; Breast- Cancer
• Link de acesso: http://hdl.handle.net/11449/124117; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/13-05-2015/000828055.pdf

INTRODUCTION: Breast cancer molecular studies are usefull to define distinct subtypes based on the identification of gene expression by cDNA microarray profile: luminal (A, B and hybrid), HER2 overexpression and triple negative. Immunohistochemical panels have been reported for identification of these subtypes with similarity with profiles of gene expression. Ultrasonography is an important imaging procedure in the characterization of breast tumors by the morphology of malignant lesions. OBJECTIVE: Differentiate the molecular subgroups described through sonographic morphologic characteristics. SUBJECTS AND METHODS: The present study is clinical, analytical and prospective. It was performed in the period from 2010 to2013 - 279 breast lesions were diagnosed with invasive ductal carcinoma at Centro de Avaliação em Mastologia (CAM) of the Department of Obstetrics, Gynecology and Breast Unit, Faculty of Medicine of Botucatu. RESULTS: The main sonographic features associated with molecular subtypes were: a) luminal - pleomorphic, thickened tissue around the tumor, no circumscribed margins, absence of microcalcifications, absent posterior acoustic shadowing effect, presence of echogenic halo and no parallel orientation to the skin; b) triple negative - oval and circumscribed lesions, normal tissue around the tumor, absence of microcalcifications, absence of posterior acoustic enhancement effect, sharp boundaries and parallel orientation the skin; c) HER2 - pleomorphic, normal tissue around the tumor, no circumscribed margins, presence of microcalcifications, heterogeneous, absent posterior acoustic effect, sharp boundaries and no parallel orientation to the skin. CONCLUSION: Statistically significant differences were found between distinct sonographic features and immunohistochemical subtypes studied