Biomarcadores cardíacos em cães com degeneração mixomatosa da valva mitral submetidos a um programa de condicionamento físico

• Ano de defesa: 2015
• Autor(a) principal: Tristão, Ana Paula Pinto Araújo [UNESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual Paulista (Unesp)
• Palavras-chave em Português: Cão; Coração - Doenças; Exercícios físicos; Peptídeos; Marcadores bioquímicos; Valvula mitral; Peptides
• Link de acesso: http://hdl.handle.net/11449/128170; http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/17-09-2015/000849676.pdf

As opposed to human medicine, which already uses the exercise as a therapeutic tool in several heart diseases, it is not common sense for small animal practitioners to recommend such treatment for dogs with heart disease owing to an absence of studies. Cardiac biomarkers may be used to monitor response to treatment and physical activity. Therefore, this study had to goal of assessing how these substances perform in dogs with myxomatous mitral valve disease (MMVD) undergoing a physical exercise program. For this purpose, 15 dogs were ascribed to three groups (in accordance with the leftatrium- to-aorta ratio). Incremental exercise test was performed to detect the lactate threshold. In the following eight weeks, the animals underwent training exercises based on 70% of the lactate threshold velocity. Echocardiographic parameters and cardiac biomarkers (NT-proANP, NT-proBNP, Cardiac troponin I, CK-MB, LDH I and AST) were evaluated at the starting time (M0), and at 4 (M4) and 8 (M8) weeks after the beginning of the exercise protocol. In the LA/Ao <1.4 group, a significant difference was found in NT-proANP at M8 as compared to M0. No differences were documented for the remaining biomarkers throughout the training. Using multivariate analysis, 8 factors were extracted. Factor 1, which comprises fractional shortening and ejection fraction, represented 17.05% of the data variability, while the factors composed by biomarkers showed lower representativeness. Based on these results, it was concluded that the systematic exercise, at least the way it was performed in this investigation, did not promote changes in the concentrations of both the stretch and myocytes injury biomarkers. In addition, multivariate analysis showed that the factors in which biomarkers were included accounted for the lowest part of the total data variability, indicating the low representativeness of these substances in the effects attributed to physical training