Detalhes bibliográficos
| Ano de defesa: |
2016 |
| Autor(a) principal: |
Santos, Jéssica Luana dos
 |
| Orientador(a): |
Rangel, Ana Lúcia Carrinho Ayroza
|
| Banca de defesa: |
Busato, Mauro Carlos Agner
,
Souza, Ricardo Sampaio de
|
| Tipo de documento: |
Dissertação
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
eng |
| Instituição de defesa: |
Universidade Estadual do Oeste do Parana
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação Stricto Sensu em Odontologia Nível de Mestrado
|
| Departamento: |
Odontologia
|
| País: |
BR
|
| Palavras-chave em Português: |
|
| Palavras-chave em Inglês: |
|
| Área do conhecimento CNPq: |
|
| Link de acesso: |
http://tede.unioeste.br:8080/tede/handle/tede/747
|
Resumo: |
Objective: The aim of this study was to investigate the beta catenin, geminin and MCM2 expression in sporadics and syndromics keratocystic odontogenic tumors (KCOTs). Material and Methods: Clinical data from 40 cases of KCOTs (30 syndromic and 10 sporadic cases) were coleted and sections from they were immunohistochemically stained and assayed for beta catenin, geminin and MCM2. Results: Sattelites cysts and cellular pleomorfism were more prevalent in syndromic cases. The beta catenin staining pattern was membranous and its reactive extension does not show statistical difference between syndromic and sporadic KCOTs, whereas the syndromic lesions showed less intense reactivity for beta catenin. The reactivity for geminin and MCM2 in both groups showed a nuclear staining pattern. In these groups, the nuclear staining occurred predominantly in the first suprabasal layer. There is no statistical difference in the geminin reactivity between the groups, whereas the means of MCM2 positive cells was higher in sporadic KCOTs than syndromic KCOTs group (p=0.011). Conclusion: Histological features shows evidences of greater aggressiveness in syndromic KCOTs, but there is not significant evidence that ensures the higher proliferative potencial of syndromic KCOT using these markers |
