Susceptibilidade de cepas de Candida albicans isoladas de secreção vaginal frente às micocinas de Wickerhamomyces anomalus

• Ano de defesa: 2021
• Autor(a) principal: Rosseto, Lana Rubia Backes
• Orientador(a): Gandra, Rinaldo Ferreira
• Banca de defesa: Gandra, Rinaldo Ferreira , Marek, Carla Brugin , Gasparetto, André
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual do Oeste do Paraná; Cascavel
• Programa de Pós-Graduação: Programa de Pós-Graduação em Ciências Farmacêuticas
• Departamento: Centro de Ciências Médicas e Farmacêuticas
• País: Brasil
• Palavras-chave em Português: Wickerhamomyces anomalus; Micocinas; Candida albicans
• Palavras-chave em Inglês: Wickerhamomyces anomalus; Mycocins
• Área do conhecimento CNPq: CIENCIAS DA SAUDE::FARMACIA
• Link de acesso: http://tede.unioeste.br/handle/tede/5692

Mycocins are substances that show a potential to affect sensitive fungi or bacteria. Wickerhamomyces anomalus is a mycocins producing yeast that has great biotechnological potential and is highly competitive in many habitats as it is adaptable to a wide range of growing conditions. Thus, they are targets of studies in different areas, including environment, industry and medical sciences. Candida albicans yeasts are of great importance because of the high frequency with which they colonize and infect the human host. And often, fungal infections are difficult to treat, a fact related to the acquisition by their etiologic agents of antifungal resistance. Due to this great resistance problem, new treatment alternatives are being studied. The objective of this work is to verify the inhibition of C. albicans isolated from vaginal secretion by W. anomalus. Tests were performed in solid medium and microdilution test, where the mycocins were efficient inhibiting the growth of C. albicans. Hemolysis and irritation tests in organotypic model, which showed that the mycocins produced by W. anomalus is safe and no irritating. Thus, the results of this work may provide scientific evidence for the application of mycocins in the production of new antifungal alternatives.