Produção de filmes de PBAT/PLA por eletrofiação para liberação de nitrofurazona

• Ano de defesa: 2018
• Autor(a) principal: Megliorini, Leonardo de Souza
• Orientador(a): Dragunski, Josiane Caetano
• Banca de defesa: Dragunski, Josiane Caetano , Tarley, Cesar Ricardo Teixeira , Rosa, Maurício Ferreira da
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual do Oeste do Paraná; Toledo
• Programa de Pós-Graduação: Programa de Pós-Graduação em Química
• Departamento: Centro de Engenharias e Ciências Exatas
• País: Brasil
• Palavras-chave em Português: Nitrofural; Nanofibras; Perfil de dissolução
• Palavras-chave em Inglês: Nanofibers; Dissolution profile
• Área do conhecimento CNPq: CIENCIAS EXATAS E DA TERRA::QUIMICA
• Link de acesso: http://tede.unioeste.br/handle/tede/4082

Nitrofurazone is a drug used to treat burns and skin transplants. The drug product is salled in cream and solution form. The ecovio® polymer is composed of poly(lactic acid) / poly(butylene adipate co-teraphtalate) and is biocompatible. In this work a film with the combination of ecovio® and nitrofurazone was produced by the electrospinning technique forming nanofibers. Two films were produced. The first was produced with dimethylformamide / tetrahydrofuran (15:85 v / v) and was capable of releasing 100% of the nitrofurazone reproducibly in the dissolution profile test evaluated for 300 minutes. The second film was produced with dimethylformamide/chloroform (15:85 v/v) and released about 90% of the nitrofurazone. But did not show reproducible results in the same range. Physicalchemical analyzes lead to the conclusion that the interaction of nitrofurazone with the polymer occurs mainly among the more polar groups. The dissolution test was performed following pharmacopoeial parameters. The quantitation of the released nitrofurazone was performed by UV-Vis spectrophotometry at 375 nm. The method used was validated and proved to be adequate, showing linearity in range 0.25 - 12.50 mg.L-1 with correlation coefficient 0.9999, high precision with relative standard deviation ≤ 1.6%, accuracy 98.9 - 100.4%, selectivity and limit of quantification 0.4 mg.L-1.