Alterações antropométricas, hemodinâmicas, hematológicas e bioquímicas na pré-eclâmpsia

• Ano de defesa: 2017
• Autor(a) principal: Freitas, Márcia Aires Rodrigues de
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Uberlândia; Brasil; Programa de Pós-graduação em Genética e Bioquímica
• Palavras-chave em Português: Pré-eclâmpsia; Preeclampsia; Ganho de peso; Weight gain; Células vermelhas do sangue; Red blood cells; Estabilidade de membrana; Membrane stability; Estabilidade osmótica; Osmotic stability; Hemograma; Hemogram; Lipidrograma; Lipidogram; Eritrócitos; Erythrocytes; Lise mecânica; Mechanical lysis; CNPQ::CIENCIAS DA SAUDE
• Link de acesso: https://repositorio.ufu.br/handle/123456789/21030; http://dx.doi.org/10.14393/ufu.te.2018.46

Preeclampsia (PE) is classified in early- (EOPE) and late-onset PE (LOPE) when pre-sent before or after 34 gestation weeks, respectively. This transversal study aimed to investi-gate the differences and possible associations existing in the anthropometric, hemodynamic, hematologic and biochemical profiles of late- and early-onset preeclampsia. The study in-cluded 65 volunteers admitted to a tertiary hospital in Brazil, 29 normotensive and 36 with preeclampsia (13 with EOPE and 23 with LOPE). Pregnant women with LOPE presented greater weight gain and borderline increase in body mass index at the end of gestation in rela-tion to the other groups, which is compatible with the metabolic origin, associated with obesi-ty, attributed to this form of the disease. Pregnant women with EOPE presented a borderline reduction in the number of erythrocytes and a significant decrease in the number of platelets, in addition to a significant increase in reticulocytes, serum iron and ferritin when compared to normotensive pregnant women and pregnant women with LOPE. A significant increase in osmotic stability of erythrocytes was observed in the EOPE group in relation to groups. He-modynamic analysis by Doppler ultrasonography of the ophthalmic artery showed that both groups of pregnant women with PE presented alterations compatible with the occurrence of hyperflow in the orbital territory. These hemodynamic changes were associated with changes in hematimetric indices