Estabilidade osmótica de eritrócitos em homens idosos com doença renal crônica em tratamento conservador.

• Ano de defesa: 2019
• Autor(a) principal: Andrade, Lucas Tadeu
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Uberlândia; Brasil; Programa de Pós-graduação em Ciências da Saúde
• Palavras-chave em Português: Envelhecimento; Eritrócitos; Estabilidade da membrana; Doença renal crônica; Neocitólise; Neocytolysis; Aging; Erythrocytes; Membrane stability; Chronic kidney disease; Ciências Médicas; CNPQ::CIENCIAS DA SAUDE
• Link de acesso: https://repositorio.ufu.br/handle/123456789/26226; http://dx.doi.org/10.14393/ufu.te.2019.2184

Introduction: Chronic kidney disease (CKD) affects approximately 10% of the adult population worldwide. Little is known about the osmotic stability of erythrocytes in the early stages of chronic kidney disease (CKD), especially in the elderly. Materials and methods: The population of this study consisted of 30 elderly men, half in the early stages of CKD and half without the disease. Curves of lysis of erythrocytes as a function of the decrease in NaCl concentration were used to determine H0, H50 and H100, which represent NaCl concentrations where lysis begins, reaches its intermediate point and ends, respectively, in addition to dX, which represents ¼ of the variation in saline concentration required to promote lysis of the entire erythrocyte population. Results: Lower H100 (p<0.05) and greater dX (0.05<p<0.10) values were found in diseased individuals, which means that they have osmotically more stable erythrocytes, probably due to the predominance of older erythrocytes, since the sick population had lower bilirubin levels and reticulocyte counts. This predominance of old erythrocytes may be due to decreased erythropoiesis, since the reticulocyte index of the CKD group was lower (0.05<p <0.10) than in the control group, and/or by elevation of neocytolysis, which is the selective destruction of young erythrocytes. Conclusion: Elderly men in early stages of chronic kidney disease on conservative treatment had higher osmotic stability of erythrocytes, suggesting that the influence of the disease on these cells is prevailing in relation to the influence of increasing age