Efeito protetor do extrato de tomate (Licopersicon esculentum) orgânico contra a ação genotóxica da doxorrubicina, pelo teste SMART de asa, em Drosophila melanogaster

Detalhes bibliográficos
Ano de defesa: 2007
Autor(a) principal: Dutra, Elaine Silvia
Orientador(a): Não Informado pela instituição
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de Uberlândia
BR
Programa de Pós-graduação em Genética e Bioquímica
Ciências Biológicas
UFU
Programa de Pós-Graduação: Não Informado pela instituição
Departamento: Não Informado pela instituição
País: Não Informado pela instituição
Palavras-chave em Português:
Link de acesso: https://repositorio.ufu.br/handle/123456789/15900
Resumo: Food that is rich in carotenoids is used in the population s common diet, and is found in fruits and other vegetables of red pigmentation, such as tomatoes, watermelons and carrots. These carotenoids are anti-oxidizing agents that capture free radicals, which are highly reactive substances produced in the organism, and if in excess, provoke precocious old age and cancer. Licopeno is the carotenoid that is present in high concentration in tomatoes. The SMART wing test was used to verify the possible anti-genotoxic or genotoxic effects of the organic tomato in somatic cells of Drosophila melanogaster. In the verification of genotoxicity, 48- hour larvae were used, and they are descendant from pattern cross (ST) and from high bioactivation capacity, and were treated with aqueous extract of TOR organic tomato (100%, 50% and 20%). The present study aimed at verifying the organic tomato genotoxic effects against the DXR genotoxic action (0,125 mg/ml), which generate free radicals. The results obtained showed that in the descendants of both crosses (ST and HB), treated as TOR, it was not possible to verify statistically significant increases in the frequencies of mutant spots in both descendants (ST and HB). This increase of frequencies of spots may suggest, at first sight, an enhancement effect of DXR. However, we can see that the increase in total frequency of spots is due to a significant increase in frequency of small spots, which leads us to believe that this effect is in reality not enhancement, but protector. This way, we can conclude that the aqueous extract of organic tomato is not genotoxic and may have an important role as anti-genotoxic agent.