Alterações dos marcadores inflamatórios, bioquímicos e aptidão física em mulheres em recuperação do câncer de mama após treinamento resistido não linear: um estudo piloto

• Ano de defesa: 2017
• Autor(a) principal: Leite, Marco Aurélio Ferreira de Jesus
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Uberlândia; Brasil; Programa de Pós-graduação em Ciências da Saúde
• Palavras-chave em Português: Ciências médicas; Mamas - Câncer; Hormonioterapia; Inflamação; Treinamento de força; Perfil inflamatório; Cancer; Strength training; Inflammatory profile; CNPQ::CIENCIAS DA SAUDE::MEDICINA
• Link de acesso: https://repositorio.ufu.br/handle/123456789/19784; http://doi.org/10.14393/ufu.di.2017.419

Introduction: Oncological treatments can provide several adverse effects in patients with breast cancer (BC), such as high inflammatory process and dyslipidemia. To date, the effect of nonlinear periodized resistance training (NLRT) on inflammatory and biochemical variables in women recovering from CM has not yet been known. Objective: To verify the effect of NLRT on the inflammatory, biochemical profile, physical fitness and body composition in women in CM recovery during hormone therapy. Methods: The assessments were done before and after 3 months of application of a NLRT program, consisting of three sessions of exercise per week on non-consecutive days. The normality of the data was verified by the Shapiro-Wilk test and the comparisons of results were performed by the paired t or Wilcoxon’s tests. Statistical significance was set at 5% (alpha = 0.05). Results: There were no significant changes in the plasma concentration of the analyzed cytokines (TNF-a, IL-4, IL-6, IL-10, IL-17, IL-1RA, IFNY), but a significant increase in salivary levels of immunoglobulin A (IgA) was observed after the intervention (186.29%). Significant increases were also observed in HDL-cholesterol (17.98%), fat-free mass (2.99%), lean mass (2.97%), and muscle strength (39.16%) and endurance (65.66%). On the other hand, significant reductions were observed in the blood levels of triglycerides (-14.40%) and total (-4.81%) and LDL- cholesterol (-10.23%), in the platelets (-7.90%) and monocytes counts (-38.89%), in the amount of fat mass (-4.53%) and in the percent body fat (-1.19%). Conclusion: Twelve weeks of NPRT led to an increase in salivary IgA concentration and improvement in body composition, lipid profile and physical fitness of women under recovery from BC treatment and under hormone therapy.