Efeito da oxigenação hiperbárica na quantidade de mastócitos durante o reparo ósseo

• Ano de defesa: 2015
• Autor(a) principal: Carneiro, Rodrigo Paschoal
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Uberlândia; BR; Programa de Pós-graduação em Odontologia; Ciências da Saúde; UFU
• Palavras-chave em Português: Reparo ósseo; Oxigenação hiperbárica; Mastócito; Ossos - Regeneração; Bone repair; Hyperbaric oxygenation; Mast cell; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
• Link de acesso: https://repositorio.ufu.br/handle/123456789/17024; https://doi.org/10.14393/ufu.di.2015.312

Hyperbaric oxygen (HBO) treatment consists in the inhalation of pure oxygen under pressure, which has been used for improve the repair of damaged tissues as well as in the prevention or treatment of tissue necrosis. This therapy has shown positive effects on bone healing with increased osteogenesis and angiogenesis. This study aimed to evaluate the effect of HBO on bone healing through the evaluation of histological (qualitative) and morphometric (bone formation and mast cell count) parameters. Fourty rats were distributed into four groups with 5 animals each (control and HBO). Bone defects were created and the animals in the experimental group were subjected to HBO sessions (90minutos under 2.5 ATA pressure). After 1, 3, 5 and 7 days the animals were euthanized, femurs were removed, processed and analyzed histologically. HBO reduced the amount of mast cells only in the period of 3 days. There was a significant difference in the percentage of bone matrix between the control group and HBO within 5 days. In general, hyperbaric oxygenation fastened the resolution of inflammation and bone repair within one week.