Alterações no controle autônomo do funcionamento cardiovascular em adultos como resultado do hipotireoidismo gestacional durante a vida fetal

• Ano de defesa: 2020
• Autor(a) principal: Alves, Juliana Milan
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Uberlândia; Brasil; Programa de Pós-graduação em Ciências da Saúde
• Palavras-chave em Português: Pressão arterial; Barorreflexo; Frequência cardíaca; Hipotireoidismo gestacional; Doenças cardiovasculares; Índice simpatovagal; Arterial pressure; Baroreflex; Heart rate; Gestational hypothyroidism; Cardiovascular diseases; Sympathovagal index; CNPQ::CIENCIAS DA SAUDE::MEDICINA; Cardiotocografia; Hipotireoidismo
• Link de acesso: https://repositorio.ufu.br/handle/123456789/31509; http://doi.org/10.14393/ufu.di.2020.782

Currently, it is known that internal and external stimuli to the intrauterine environment during fetal development can have important physiological consequences in the individual's adult life. Several studies have shown that different diseases in adulthood may have their origin in the early stages of life. A decrease in maternal thyroid hormone levels, as in gestational hypothyroidism (GHT) cases and during the lactation period, is related to problems in fetal heart development and long-term cardiovascular diseases. However, the mechanisms behind these effects are not yet fully understood. Therefore, the aim of this work was to evaluate the cardiovascular consequences in adulthood caused by GHT during gestation and lactation periods. Material and methods: We investigated this by measuring the arterial pressure, heart rate, baroreflex function and autonomic cardiovascular control of adult Wistar rats that underwent fetal and neonatal GHT. As results, we found that the offspring of rats with induced hypothyroidism during pregnancy and/or lactation showed significantly less weight gain in the first 90 days after birth. These rats also presented an increase in both mean arterial pressure and systolic blood pressure, in addition to an increase of the sympathovagal index when compared to the control group. In conclusion, our results showed that maternal thyroid hormone deficiency can chronically produce changes in cardiovascular function in the adult life of the offspring.