Desenvolvimento de nanopartículas de canabidiol com propriedades analgésicas

• Ano de defesa: 2024
• Autor(a) principal: Goulart, João Pedro Tannús
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso embargado
• Idioma: por
• Instituição de defesa: Universidade Federal de Uberlândia; Brasil; Programa de Pós-graduação em Genética e Bioquímica
• Palavras-chave em Português: Carreadores lipídicos nanoestruturados; Lipid nanocarriers; Analgésico; Analgesic; Cannabis; Canabidiol; Cannabidiol; CNPQ::CIENCIAS DA SAUDE::FARMACIA::FARMACOTECNIA; CNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERAL; Genética; ODS::ODS 3. Saúde e bem-estar - Assegurar uma vida saudável e promover o bem-estar para todos, em todas as idades.; ODS::ODS 12. Consumo e produção responsáveis - Assegurar padrões de produção e de consumo sustentáveis.
• Link de acesso: https://repositorio.ufu.br/handle/123456789/43511; http://doi.org/10.14393/ufu.di.2024.5147

Cannabis has become a promising candidate for the treatment of pain, when compared to other alternatives, having analgesia among its main characteristics. The present work developed nanostructured lipid carriers (NLC) composed of vegetable butter and surfactant that encapsulate cannabidiol (CBD) oil with the aim of preventing or managing pain. The NLCs exhibited physicochemical stability for 365 days (25 °C) in relation to particle size (nm), polydispersity index and surface electrical charge (mV). The in vivo nanotoxicity study in a chicken embryo model determined that this formulation did not induce nanotoxicity in any of the evaluated parameters. Furthermore, the in vivo analgesic activity in Drosophila melanogaster larvae elucidated the effectiveness of CBD oil-based formulations in the biological model tested. Based on the results obtained, it can be concluded that nanostructured lipid carriers developed to encapsulate cannabidiol oil demonstrate to be an effective and safe approach to pain management, presenting prolonged stability and absence of toxic effects, in addition to showing significant analgesic activity in tested biological models.