Manual prático de desenvolvimento de cosméticos aplicados à regeneração cutânea

• Ano de defesa: 2019
• Autor(a) principal: Yamaguchi, Eliana Mika [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Manual de Referência; Regeneração tecidual guiada; Cosméticos; Desenvolvimento; Pele
• Link de acesso: https://repositorio.unifesp.br/handle/11600/58406

Introduction: The cosmetic category that comprises skin care, sunscreens, and others, is an important segment of personal care products, whose opportunity to develop new cosmetics, and derma-cosmetics products for skin treatments has a market which can be developed in Brazil. The search for innovation is paramount in order to meet these needs and to cognize the fulfillment of many steps and directives established by governmental agencies. Fostering the development of new cosmetic products that assist in the process of cutaneous regeneration and healing is an area to be developed and the elaboration of a practical handbook on cosmetics development would facilitate access to information and the development of dermo-cosmetics applied to cutaneous regeneration. Objective: Develop and validate a practical handbook for the development of cosmetics applied to cutaneous regeneration. Method: The dissertation was elaborated as a descriptive study. The research was divided into five stages. The first stage involved the bibliographic survey conducted from January 2015 to December 2018 in the following databases: LILAC´s, MEDLINE via PUBMED, WEB OF SCIENCE, and SCOPUS, using the descriptors: reference handbook, guided tissue regeneration, cosmetics, development, and skin. The second stage was the development of the structure of the handbook and meetings with pharmacists applying Design Thinking tools, which included a content survey and content selection and filing. The third stage consisted of visual communication, textual elaboration, the creation of illustrations, infographics, and diagramming. The fourth stage involved the validation of the handbook using the Delphi Technique, through consultations with chemical and pharmaceutical specialists, using the inclusion criteria of at least 10 years of experience in the development area; adequacy of the handbook; and Portuguese review. The fifth stage includes the registration in the ISBN and disclosure of the handbook. Results: In the first stage, a total of 3,459 articles were found, of which 249 were duplicated, resulting in 3,210 articles. The articles were selected based on reading their title and summary, through which 51 articles were selected and read in their entirety. In the second stage, the structure of the handbook was defined applying Design Thinking, which was composed of 8 chapters, introduction, objective, product development, checklist, glossary, references, specific legislation in the area, and flowcharts. In the third stage, visual communication and diagramming were defined. In the fourth stage, seven pharmaceutical and biochemical judges validated the work using the Delphi Technique and the Content Validation Index (CVI), and within two rounds there was an agreement of 100% between the judges. The Objective item obtained an IVC of 1.0, Structure and Presentation was 1.0, and Relevance was of 1.0. The overall IVC was 1.0, reaching the validation target of at least 0.90. In the fifth stage, the Editorial Prefix was registered in n. 900986 and ISBN n. 978-65-900986-1-0 with the National Library. Conclusion: The Practical Handbook for the development of cosmetics applied to cutaneous regeneration was developed and validated.