Efeitos do consumo de oleaginosas sobre os níveis de adiponectina e interleucina-6 em adultos e idosos com diabetes tipo 2

• Ano de defesa: 2016
• Autor(a) principal: Strufaldi, Maristela Bassi [UNIFESP]
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de São Paulo (UNIFESP)
• Palavras-chave em Português: Diabetes mellitus; Adiponectin; Interleukin-6; Adiponectina; Interleucina
• Link de acesso: https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=3647986; http://repositorio.unifesp.br/handle/11600/46628

Objective: To investigate the effects of oilseed consumption on adiponectin levels of high molecular weight (HMW ADIPO) and interleukin-6 (IL-6), and on the nutritional status, glycemic control and lipid profile in adults and older adults with diabetes type 2. Methods: A prospective, randomized, controlled study conducted from February 2013 to June 2014, involving 60 individuals with type 2 diabetes were randomly divided into two groups: control (CDM) and supplemented with oleaginous (SDM). All participants received hypocaloric diet guidance, composed of 50% carbohydrates, 20% protein and 30% lipids, limited to up to 7% of saturated fatty acids, 15% monounsaturated fatty acids and 10% of fatty acids polyunsaturated. The SDM group also received a daily supplement of 30 grams of oleaginous (7.5 g of walnuts, 7.5 g of Brazil nuts, 7.5 g of almonds and 7.5 g of cashew nuts). Both groups were followed for 12 weeks, with monthly individual consultations and laboratory evaluation at the initial and end of the study. Results: The final study, 28 (93.3%) subjects in the CDM group and 24 (80%) of the SDM group. Both groups showed improvement in glycemic control observed for fasting glucose (CDM: p = 0.009; SDM: p = 0.003) and glycated hemoglobin (CDM: p = 0.010; SDM: p = 0.002) and significant (p <0.001) weight reduction, body mass index (BMI), waist circumference (WC) and body fat percentage (BFP); the differences between the groups were not significant. In comparing the initial and final levels of HMW ADIPO and IL-6, the differences were not statistically significant in both groups. Considering the total study sample it was observed that the greater the reduction of BMI and BFP, higher were the final levels of HMW ADIPO (BMI: p <0.001; BFP p = 0.003); for IL-6, the differences were significant in relation to WC (p = 0.033) and BFP (p = 0.019). Conclusion: There were no differences with statistical significance between the initial and final levels of ADIPO HMW and IL-6 in both the control group and in the group supplemented with oil. The two groups have benefited from individualized nutritional counseling, with decreased weight, BMI, BFP and improved glycemic control.